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NFT: Technological change and cancer treatment: new news.

manh george : 2/27/2015 9:00 am
I am an amateur who is fascinated with the implications of accelerating technological change. Some are challenging--more and more jobs potentially obsolesced by automation of various kinds. Some are pretty unambiguous good news, with likely new cancer treatment techniques at or near the forefront. There has been quite a bit written on the nascent but growing use of autoimmune techniques to attack cancers, for example.

Now, there are two new announcements regarding techniques in their early stages, with very impressive potential outcomes. One involves the use of a blood test to identify existence of a tumor. At least in trials, the tests unambiguously differentiate between blood from a patient with certain types of tumors and those without.

http://news.xinhuanet.com/english/2015-02/24/c_134013415.htm

In the other, really promising treatment options for pancreatic cancer are becoming available, also in tests.

Quote:
The research, published in esteemed science journal Nature on Thursday, examined the variations in the genome present in 100 pancreatic adenocarcinomas the type most frequently diagnosed.

This allowed the cancers to be further divided into four categories: stable, locally rearranged, scattered and unstable.

Several of the cancers were also found to have mutations amenable to treatment with drugs used for other cancers, and not at present for pancreatic cancer. In addition, two novel gene mutations were observed which may offer leads for new approaches to treatment.

Adjunct Associate Professor Nikolajs Zeps of the University of Western Australia said on Friday the study was a good illustration of the power of biobanks linked to genomic sequencing...
(link)

With pancreatic cancer currently having a 5-year death rate of 95%, this is potentially huge. If it can be linker to earlier detection, even huger. Most pancreatic cancer isn't diagnosed until stage 3, as I understand it.
Link - ( New Window )
My Father-in-Law died of pancreatic cancer  
Ben in Tampa : 2/27/2015 9:26 am : link
Truly horrible. He barely lived 12 months once diagnosed. I am hoping they find a way to drastically improve the chances of surviving.
Here's a link to the first article you mentioned  
Ira : 2/27/2015 9:39 am : link
.
Link - ( New Window )
Interesting - thanks for posting  
cosmicj : 2/27/2015 9:46 am : link
this. One of my colleague's husbands just died of pancreatic cancer. He was in apparently perfect health as recently as October. A frightening type of cancer.
Two years ago I read a fascinating article in  
SwirlingEddie : 2/27/2015 10:12 am : link
Esquire Magazine about "Patient Zero", a women diagnosed with recurrence of colon cancer who was the test case for some amazing genetic sequencing of her cancer and targeted treatments based on those tests. The OP prompted me to revisit the article and I was dismayed to read that the women passed away just this month. Much progress is being made, but the fight goes on.
Epigenomics  
RAIN : 2/27/2015 2:29 pm : link
I worked on a project to make a blood based test for cancer based on epigenetic markers. The test is 90% specific for colon cancer in a gene called septin-9. If this gene is "methylated" in the circulating blood and is detected.. it's 90% specific for colon cancer. The tumor, however big or small, will shed it's cells and dna and it will ciruclate in the blood. The test was able to catch things in stage 1 or 2, which is a huge bonus.

Problem is.. the science is good, but the test hasn't gained much traction in the US for reasons unknown, despite it being successful in a 10,000 patient study. Politics? Who knows.
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