New anti-migraine drug: good news for Sterling Shepard?

My all-time favorite job would be as nutrition/health consultant for my NY Giants. If I had ShepÕs ear, IÕd tell him to try high-dose magnesium first before taking drugs. Most people are deficient in magnesium and could benefit in many ways, especially for constipation, fatigue, cramps, depression, insomnia, hypertension or high blood sugar. Another nutrient for migraine is high-dose riboflavin (B2). Because migraines are inflammatory, I would also try fatty fish, fish oil or cod liver oil and vitamin D3, or ample sunshine. These nutrients are not limited to just headache relief, but can provide many benefits, as long as they are of high quality, and balanced with a healthy diet. I talk about these issues on my blog: https://thescienceofnutrition.me

Thanks for listing the above.

Thanks...

You have a headache? Bad one too? Strap up and play snowflake.












Kidding.

Nutritional solution don't make drug companies any money

working in Neurology, as a specialty. This is huge news for the migraine headache population. The studies are incredibly promising with less side effects prevalence then the current preventative migraine therapy. As a whole, the patient will enjoy less frequency of occurrence and severity of the migraine headaches, as well as less side effects compared to the current treatments. This will definitely benefit players like Sterling Shepherd. I hope they are adequately covered by insurances for my patients. Can't wait to try the CGRP inhibitor on my first patient. My migraine patients are very much aware of this medication and are looking forward to it.

What are the side effects of drugs that affect brain chemistry?

these drugs are going to be very expensive.

In comment 13967299 XBRONX said:

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What are the side effects of drugs that affect brain chemistry?

Dry mouth and fatigue are the most common complaints we hear about, just as the article points out. We use amitriptyline a lot, which is and an old anti-depressant called a tricyclic antidepressant that prolongs the activity of neurotransmitters called serotonin and norepinephrine. You can get a sedating side effects that work similar to the anticholinergics like muscle relaxers. It can also cause weight gain and constipation. Another common medication we use for preventative migraine therapy is toperimate (Topamax) which is also an antieliptic. This can also make you fatigued and place you into "a brain fog" as well as numbness in hands and feet and weight loss. Most of the meds are tolerated, but they are not for all and it is difficult to treat these patients, because these side effects can just as much effect the everyday activity as the migraine headache itself. That and the efficacy shown in the data makes it at breakthrough type of medication. We are very hopeful.

Try natural healthy solutions first before delving into potentially toxic and expensive drugs. From my studies, I'd say theyÕll help in most cases. And magnesium is special. If you are taking any supplements, make sure one is chelated magnesium, like mag taurate, glycinate, threonate, malate, or citrate, but not mag oxide. Even Epsom salts in the bathtub can be beneficial for many ailments, including migraines.

In comment 13967452 Phiddler said:

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Try natural healthy solutions first before delving into potentially toxic and expensive drugs. From my studies, I'd say theyÕll help in most cases. And magnesium is special. If you are taking any supplements, make sure one is chelated magnesium, like mag taurate, glycinate, threonate, malate, or citrate, but not mag oxide. Even Epsom salts in the bathtub can be beneficial for many ailments, including migraines.

I definitely concur that first line therapy should be less invasive; however, we must be careful of some of these herbal remedies and their potential side effects as these types of medications are not a scrutinized in studies as others. I would consult your internist or family physician before trying some of these medications. I would go as far as acupuncture or OMM therapy for manipulation as an alternative.

Biggest ripoff on the drug market are anti depressive for mild to moderate depression. L tryptophan works better

In comment 13967690 XBRONX said:

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Biggest ripoff on the drug market are anti depressive for mild to moderate depression. L tryptophan works better

I agree; however, there is some beneficial medications for antidepressants that are out there. Case in point, Wellbutrin appears to be a very good drug more so for keeping focused and improving concentration to help maintain your memory when dealing with postconcussive syndrome. You are killing two birds with one stone for that matter in dealing with depression also. L-tryptophan is beneficial, as it is a dietary supplement. I've always preached to my patients that good sleep hygiene and good diet to help maintain mental health. In the case of amitriptyline, we do not use is as much for anti-depressive; but instead for pain control and headaches.

In comment 13967152 chopperhatch said:

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You have a headache? Bad one too? Strap up and play snowflake. Are you an asshole ALL the time? Kidding.

are side effects from dietary supplements. IÕd be far more worried about the side effects of drugs. Sure, there are questionable practices and cheap ingredients in some supplements, esp. the drugstore crap. But there are many excellent companies that make safe and useful supplements. Asking your physician about them is like asking a janitor to teach a class in physics. They know virtually nothing about nutrition, and most of them are in cahoots with the big drug companies. They get major kickbacks from selling their drugs. I donÕt know of a single magnesium supplement thatÕs ever hurt anyone, and this is my field. And I am an expert in this area of health, unlike most physicians. It might give you diarrhea if you take too much, but just take less to find the right dose, or find the right source of magnesium that works for you. I highly recommend magnesium taurate or threonate for migraines. It wonÕt hurt you, and will cost you $15-$20 for a couple months supply. ThatÕs enough time to tell if it will help you or not, and youÕd be surprised at all the benefits. Taking drugs for ailments that readily respond to vitamin/mineral therapy is absurd, and downright criminal. Dr. Phil (no, not that fat guy on TV).