this coming Saturday. I am very excited. Turns out that I am “essential” since I work w kids. Has anyone been vaccinated yet who can speak to the side effects?
both shots. I am not looking forward to going through that again with this one. I'll have to plan on being in bed the whole next day after this vaccine. Hope for a better experience.
My sister and brother-in-law got it and had no effects
My wife and mother-in-law got their first shot of the Pfizer vaccine yesterday. My father got his first shot of the Moderna vaccine earlier today. My wife's arm was sore the first day. No effects today. My father hasn't had any effects whatsoever so far.
Friday. Yesterday I had chills, fever of 102, major headache, muscle aches, everything. Around 5 pm I took some Tylenol and was totally fine 90 min later. Today I feel like a million bucks.
2 weeks before my hip revision
Worth getting vaccine if I had it already?
Wife just got her 2nd Pfizer shot today
Little bit of a sore arm, tingling , itchy throat for a little
But nothing worth noting
has gotten both of her shots as she works as an ER tech. She said she had no side-effects aside from the normal pain in the arm where the shot was administered.
Was sick for 3 to 4 days from the first Moderna shot. She even went for two COVID tests to rule that out. Better now. Will be prepared when second shot us given.
my sister in law is a home healthcare nurse and the first Pfizer injection she said was like a flu shot. It made her arm sore like a flu shot but no other noticeable issues. Interestingly, she has also had Covid with very mild symptons and is 60 years old.
I can only speak to my experience.
Jackson Memorial opened up to over 65 last Tuesday.
I clicked on the site and scheduled an appt for the following day.
I got there a half hour early and they were running ahead of schedule so they took me.
It was a smooth process and took about a half an hour start to finish.
The last thing they do is make you wait 15 minutes before you leave.
I have not had any after effects.
Good luck with yours!
both shots. I am not looking forward to going through that again with this one. I'll have to plan on being in bed the whole next day after this vaccine. Hope for a better experience.
Yeah, Shingrix made me a little punky the next day and arm sore three days. Worse 2nd shot then 1st. Took and Advil at felt better in an hour and a half.
Exactly, huge no thanks for me. Rushed vaccine, no animal trials, total violation of Nuremberg codes. Really hope the best for all you that have elected to get it and hope it works, but I’m not going to be a human guinea pig.
Exactly, huge no thanks for me. Rushed vaccine, no animal trials, total violation of Nuremberg codes. Really hope the best for all you that have elected to get it and hope it works, but I’m not going to be a human guinea pig.
Geezus. It is using known technology that has been around 15 or 20 years. That is why it was developed so fast.
Good the more idiots that don't get it means those that want it get t sooner.
With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
Interesting and completely inaccurate comment. RNAs are used quite a bit in medicine nowadays, and they are fine, but I agree there is some uncertainty longterm.
Actually there were animal trials. Furthermore there has been quite a bit of work with this type of vaccine (mRNA, Coronavirus, Ab vs the spike protein). This allowed rapid preclinical development. Was it rushed? Heck yeah!
Nuremburg codes? You've got to be kidding. I would think the results with 95% efficacy and excellent safety would be affirming on that one.
I will grant that there is some uncertainty about long-term safety, but the risk is quite small and is mostly used as an excuse by people who want to scare others or are so distrustful of medicine that they will use that as their excuse. You don't have to trust anybody and you don't have to get a vaccine, but all the experts including the independent panel that reviewed the data were all supportive.
Exactly, huge no thanks for me. Rushed vaccine, no animal trials, total violation of Nuremberg codes. Really hope the best for all you that have elected to get it and hope it works, but I’m not going to be a human guinea pig.
Interesting and completely inaccurate comment. RNAs are used quite a bit in medicine nowadays, and they are fine, but I agree there is some uncertainty longterm.
Actually there were animal trials. Furthermore there has been quite a bit of work with this type of vaccine (mRNA, Coronavirus, Ab vs the spike protein). This allowed rapid preclinical development. Was it rushed? Heck yeah!
Nuremburg codes? You've got to be kidding. I would think the results with 95% efficacy and excellent safety would be affirming on that one.
I will grant that there is some uncertainty about long-term safety, but the risk is quite small and is mostly used as an excuse by people who want to scare others or are so distrustful of medicine that they will use that as their excuse. You don't have to trust anybody and you don't have to get a vaccine, but all the experts including the independent panel that reviewed the data were all supportive.
Exactly, huge no thanks for me. Rushed vaccine, no animal trials, total violation of Nuremberg codes. Really hope the best for all you that have elected to get it and hope it works, but I’m not going to be a human guinea pig.
To those who question the long term effects of the vaccine....
Interesting and completely inaccurate comment. RNAs are used quite a bit in medicine nowadays, and they are fine, but I agree there is some uncertainty longterm.
Actually there were animal trials. Furthermore there has been quite a bit of work with this type of vaccine (mRNA, Coronavirus, Ab vs the spike protein). This allowed rapid preclinical development. Was it rushed? Heck yeah!
Nuremburg codes? You've got to be kidding. I would think the results with 95% efficacy and excellent safety would be affirming on that one.
I will grant that there is some uncertainty about long-term safety, but the risk is quite small and is mostly used as an excuse by people who want to scare others or are so distrustful of medicine that they will use that as their excuse. You don't have to trust anybody and you don't have to get a vaccine, but all the experts including the independent panel that reviewed the data were all supportive.
Thank you Bob...anti-vaxxers are a public safety hazard
With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
What other vaccine trial had people lining up to volunteer by the droves? Do you know how hard it is to get 40,000 volunteers to take an experimental vaccine? For the Covid vaccine, it was so highly publicized that people were lining up and it took weeks to get the 40,000 as opposed to month, years....
Actually the guinea pigs were the close to 100,000 people who volunteered for the trials. Some of those people were randomized to placebo and haven't gotten vaccinated yet. The preclinical part was really fast because a lot of work had already been done with prior coronaviruses and RNA viruses. The clinical trials went fast because everything was expedited by everyone for obvious reasons and there were so f'in' many people who got infected.
I do clinical research for a living (altho not for vaccines) and the clinical trial results were quite good and very transparent. I read the entire Pfizer briefing book for the FDA Ad Board mtg and much of the Moderna one. The data was very impressive
With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
Actually the guinea pigs were the close to 100,000 people who volunteered for the trials. Some of those people were randomized to placebo and haven't gotten vaccinated yet. The preclinical part was really fast because a lot of work had already been done with prior coronaviruses and RNA viruses. The clinical trials went fast because everything was expedited by everyone for obvious reasons and there were so f'in' many people who got infected.
I do clinical research for a living (altho not for vaccines) and the clinical trial results were quite good and very transparent. I read the entire Pfizer briefing book for the FDA Ad Board mtg and much of the Moderna one. The data was very impressive
In comment 15117941 beatrixkiddo said:
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In comment 15117920 oghwga said:
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With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
Let's see the snappy come backs from chiro and beatrix on that....
I will concede that there is some uncertainty about long-term effects of an RNA vaccine, (RNA can be translated to DNA and get into your cells), but the risk is small in comparison to the hundreds of thousands of deaths from Covid. The long-term risk should be small. And this type of vaccine is totally new and for it to be used in upwards of a billion people, one has to concede some element of uncertainty. But it has been extensively tested, data looks excellent and the risk is much lower to get it than to not.
Actually the guinea pigs were the close to 100,000 people who volunteered for the trials. Some of those people were randomized to placebo and haven't gotten vaccinated yet. The preclinical part was really fast because a lot of work had already been done with prior coronaviruses and RNA viruses. The clinical trials went fast because everything was expedited by everyone for obvious reasons and there were so f'in' many people who got infected.
I do clinical research for a living (altho not for vaccines) and the clinical trial results were quite good and very transparent. I read the entire Pfizer briefing book for the FDA Ad Board mtg and much of the Moderna one. The data was very impressive
In comment 15117941 beatrixkiddo said:
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In comment 15117920 oghwga said:
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With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
Let's see the snappy come backs from chiro and beatrix on that....
@section125 - I don’t post to get into pissing matches and flex my keyboard muscles with people here. So why don’t you temper your hostilities.
@ Bob - again no long term side effects have been conducted, projection is merely that, projection. Doing this on a large scale is incredibly risky IMO. Of course big pharma is going to right glowing reviews on a product they produce that will make them billions. Horrible side effects,no worries they have been granted blanket legal immunity. Get sick from taking the shot, great you can take their next solution to fix you up on the crap they made you sick with. Win-win. The regulatory agencies (FDA, etc.) are horse shit, these people on these boards all come from the pharmaceutical companies they are now supposed to regulate, That doesn’t worry you? Ok.
2 weeks before my hip revision
Worth getting vaccine if I had it already?
Wife just got her 2nd Pfizer shot today
Little bit of a sore arm, tingling , itchy throat for a little
But nothing worth noting
you would need to wait for a year or so but you can get shingles more than once. I had a rare form of shingles last year that caused facial paralysis and hearing loss. I would not wish that on anyone
@section125 - I don’t post to get into pissing matches and flex my keyboard muscles with people here. So why don’t you temper your hostilities.
@ Bob - again no long term side effects have been conducted, projection is merely that, projection. Doing this on a large scale is incredibly risky IMO. Of course big pharma is going to right glowing reviews on a product they produce that will make them billions. Horrible side effects,no worries they have been granted blanket legal immunity. Get sick from taking the shot, great you can take their next solution to fix you up on the crap they made you sick with. Win-win. The regulatory agencies (FDA, etc.) are horse shit, these people on these boards all come from the pharmaceutical companies they are now supposed to regulate, That doesn’t worry you? Ok.
This isn't twitter there is no "@" needed.
Ok so you come on here dealing ignorant shit, so who is being hostile.
If you don't want the shot, that is up to you, but don't go spreading falsehoods.
I get it you don't trust pharma companies. And some are untrustworthy, so there's that. But most are responsible, and essentially all are super-scared about getting caught (which does happen) mis-representing data.
You of course are wrong that all the people on independent panels are from pharma companies, they're mostly from academia. There are super-strict rules about disclosure of payment to physicians, and if you get caught mis-representing you can go to jail.
The people from FDA drive me crazy sometimes, but they are competent, not paid very well, and are stuck between complaints about approving things too quickly and too slowly, both due to public pressure.
I was an academic physician who went into pharma. Did I compromise my morals by doing so? My friend thinks so, but there are so many rules and the penalties for mis-representing data are super-severe (if Pfizer was caught mis-representing data their stock would plummet), so if anything I think most companies are if anything overly cautious. Some are not, some of them get caught and I'm sure there are some who don't.
The long-term safety is certainly unknown since there hasn't been time to study it. But the risk is extremely low, which is why the vaccines were approved.
"Very risky" is untrue. But a little risky, OK. Risker than getting Covid? No. I don't agree with giving the companies legal immunity, if that happened I don't agree with it. In the movies these pharma companies are always depicted as having these diabolical criminals (loved the Fugitive, btw). That's not really how things work.
Actually the guinea pigs were the close to 100,000 people who volunteered for the trials. Some of those people were randomized to placebo and haven't gotten vaccinated yet. The preclinical part was really fast because a lot of work had already been done with prior coronaviruses and RNA viruses. The clinical trials went fast because everything was expedited by everyone for obvious reasons and there were so f'in' many people who got infected.
I do clinical research for a living (altho not for vaccines) and the clinical trial results were quite good and very transparent. I read the entire Pfizer briefing book for the FDA Ad Board mtg and much of the Moderna one. The data was very impressive
In comment 15117941 beatrixkiddo said:
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In comment 15117920 oghwga said:
Quote:
With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
Let's see the snappy come backs from chiro and beatrix on that....
@section125 - I don’t post to get into pissing matches and flex my keyboard muscles with people here. So why don’t you temper your hostilities.
@ Bob - again no long term side effects have been conducted, projection is merely that, projection. Doing this on a large scale is incredibly risky IMO. Of course big pharma is going to right glowing reviews on a product they produce that will make them billions. Horrible side effects,no worries they have been granted blanket legal immunity. Get sick from taking the shot, great you can take their next solution to fix you up on the crap they made you sick with. Win-win. The regulatory agencies (FDA, etc.) are horse shit, these people on these boards all come from the pharmaceutical companies they are now supposed to regulate, That doesn’t worry you? Ok.
Fact check: Coronavirus vaccine could come this year, [redacted] says. Experts say he needs a 'miracle' to be right.
Link below.
It was beaten into the public that a vaccine would take "at least" 18 months to 2 years by multiple experts and as noted in the fact check link below, it would take a miracle to have one before the end of 2020.
Well, here we are.
So, sure, maybe it's totally safe, who knows. But when the experts told you all summer it would need a miracle and that miracle actually happens, it's fine to be careful about ingesting the substance that was the fruit of that miracle.
No need to shame or bully someone who isn't willing to suddenly trust "experts" who have been all over the map on this thing. Experts of all parties and persuasions.
Here are some quotes:
This was May 15th (and just one article)
Quote:
...But experts say that the development, testing and production of a vaccine for the public is still at least 12 to 18 months off, and that anything less would be a medical miracle....
Quote:
...“I think it’s possible you could see a vaccine in people’s arms next year — by the middle or end of next year. But this is unprecedented, so it’s hard to predict,” said Dr. Paul Offit, a professor at the Perelman School of Medicine at the University of Pennsylvania and the director of the Vaccine Education Center at Children's Hospital of Philadelphia....
Quote:
...Offit spent 26 years developing a vaccine for rotavirus, a common and dangerous childhood gastrointestinal illness, before it was approved by the Food and Drug Administration in 2006. He said vaccine development typically takes decades, but that efforts to counter COVID-19 are being fast-tracked by scientists, drug companies and nations — rallied by the World Health Organization — to meet the threat posed by the coronavirus, which has killed hundreds of thousands and decimated economies across the globe....
Quote:
...Dr. Walter Orenstein, a professor at Emory University and the associate director of the Emory Vaccine Center, said a vaccine in less than a year would be “miracle.”..
Quote:
...Dr. Stanley Plotkin, credited with inventing a rubella vaccine in 1964, said developing a vaccine in a year to a year and half was “feasible,” but dependent on the efficacy of the vaccines currently in development and on the ability to mass produce them.
“In the best of circumstances, we should have a vaccine — or let's say vaccines — between 12 and 18 months," he said. "Whether those circumstances will be the best or not, we don’t know."...
Quote:
...Dr. Anthony Fauci, told the "Today" show that January 2021 is the earliest a vaccine could be ready, but cautioned that that timeline is "aspirational" and depends on companies producing a vaccine before researchers are sure it will work....
Quote:
...“A lot of optimism is swirling around a 12- to 18-month timeframe, if everything goes perfectly. We’ve never seen everything go perfectly,” Bright said. “I still think 12-18 months is an aggressive schedule, and I think it’s going to take longer than that to do so.”...
All these experts skeptical, and some guy is apprehensive about taking it and he's getting bullied and shamed on here.
GTFO.
Also, in CA almost 40% of front line healthcare workers have rejected the vaccine? Why? They cite both the relative low risk of COVID for their age group and the unknown effects of a miracle vaccine.
Quote:
...April Lu, a 31-year-old pregnant nurse at Providence Holy Cross Medical Center: Between “the risk of having COVID, or the risk of the unknown of the vaccine … I’m choosing the risk of COVID. I can control that and prevent it a little by wearing masks.”...
Take the vaccine if you want, though I think it should be given first to the people dying (the over 70 year olds or those with the co-morbities - obesity, diabetes, etc.), but don't shame people for being cautious about it. link - ( New Window )
(M.D., been seeing patients through this all) git phase 1 two weeks ago. Said her arm hurt a little and she napped tha5 afternoon. But was fine next day.
Gonna breathe easier from afar once she is fully vaccinated. Major badass, she is. Said “this is my calling and if it ends it for me, it ends it.”
Made to sound legit by being sprinkled in with various bits of truths and and half truths with things like Nuremberg codes to try to sound learned and authentic.
I hate it. It's why people don't wear masks and don't take things seriously and cherry pick their facts so they can feel like they have power over something.
I've had people tell me that Fauci should be in jail that bill gates and big pharma created the virus that masks cause syndromes worse than the disease that covid isn't all that bad I am sick and tired of all the nitwitteey I encounter on a daily basis.
I am not a smart man. I don't double down by insisting that I am smarter than Dr Fauci to make myself feel better.
Social media users are constantly bombarded by nonsense and they slurp it up and here we are a year later worse than when we started and people are pissed that they have to wear masks and can't go to bars and they demand service at establishments while not wearing a mask because they think it violates their rights.
I am done being civil to people that spread stupidity.
Sorry.
Check my history. I never argue with anyone here. I am just exhausted by the smugness I see on the self satisfied people who walk around maskless because their Facebook news feed told them not to be sheeple.
About how they were able to make the vaccine so quickly. In short, most vaccines could be make more quickly, but there isn't an incentive to do so, which obviously doesn't apply here. Everyone has the right to decide if they want to get vaccinated, but spreading falsehoods about "big pharma" is not constructive. How They Made a Vaccine So Fast - ( New Window )
Everyone is going to tell you after the miracle happens
how it happened, no one was saying before it how it was going to happen. You cannot rewrite history, almost no one thought having a vaccine this fast was possible. If that has you saying "how quickly can I get it" - then great, you're an early adopter. But (IMO) if you are reluctant, then wait until it's been given to enough people to make you comfortable. I'm not anti-vaxx, but given the circumstances here with COVID I feel like there should be tolerance for those not comfortable.
And anyway, I was mostly referring to the hesitance to take the vaccine due to the speed it was brought to market, not whatever falsehoods may have been sent and I'm pretty sure no one was influenced by the falsehoods.
RE: To those who question the long term effects of the vaccine....
nephew a doctor just took second Pfizer shot a few days ago
first shot cause arm pain cleared up in a day
second shot he felt like he was getting the flu
feeling very ill he went to bed very early that day
slept a very long night and woke up feeling better
he said every medical person he works with felt the same way after taking second shot .
RE: RE: To those who question the long term effects of the vaccine....
Please tell me the long term effects of the virus....
There were some generic studies indicating some susceptibility to ADE but Not specific to the discussed vaccines.
There was some suggestion about ADE with the original SARS, due to everyone having antibodies to one or more of the other 4 common seasonal coronaviruses, but I am not sure those studies have held up. Based on that, there was an early fear that ADE might be something to worry about with about CoV-2, but that has proven to be unfounded. There is actually little to no reactivity of antibodies with the seasonal coronaviruses and COV-2 (and vice versa). WRT vaccine, ADE should likewise not be an issue but it is worth watching the response of people who already have had COVID to the vaccine(I'm betting it's a boosted response rather than a pathological one).
One the rapidity of the vaccine relative to others, consider that most vaccines are not money makers and usually it's a company or two with a couple of scientists on the project toiling away in a vacuum for several years. With COVID, it's pretty much every scientist on the planet working in concert night and day and examining multiple per-established platforms.
And, whatever the vaccine, there absolutely were animal studies, including NHP studies.
And, the people reviewing the data prior to approval were largely academicians who were not on any company's payroll.
And, we've got data on nearly 100K people on all the vaccines. Both safety and efficacy.
I get the flu shot every year and all vaccinations and never had a side affect at all. This one made my arm really sore for a few days but nothing too bad, now I'm fine. I think it may have been the way it was shot into the muscle, and not really the vaccine itself.
I have a question. Does this vaccine address the two additional or any future strains of COVID?
So far, the vaccines are believed to be protective against the new strains. There is some suggestion that at least one of the new strains (South Africa) *might* escape from one of the monoclonal antibody therapeutics.
I have a question. Does this vaccine address the two additional or any future strains of COVID?
So far, it looks like the vaccines will work against the mutated strains. I believe it's because the vaccine targets the spike protein the virus uses to invade human cells, and these new strains have little or no mutation to that protein. Pfizer Covid vaccine ‘works against two new mutant strains’ - ( New Window )
both shots. I am not looking forward to going through that again with this one. I'll have to plan on being in bed the whole next day after this vaccine. Hope for a better experience.
Hey US1, I work in a rehab hospital. The majority of us have gotten the first Covid vaccine shot already. Everyone that also had the Shingrix shot said that it was much worse than the Covid vaccine. I haven't gotten the shingles shot myself, but seems to be a rough one. But compared to the pain that comes with shingles it was probably worth it
I have a question. Does this vaccine address the two additional or any future strains of COVID?
So far, it looks like the vaccines will work against the mutated strains. I believe it's because the vaccine targets the spike protein the virus uses to invade human cells, and these new strains have little or no mutation to that protein. Pfizer Covid vaccine ‘works against two new mutant strains’ - ( New Window )
Well, it actually has several mutations in the spike, including a deletion. IIRC only one mutation in the part of the spike which interacts with the host cell and so, it looks like there are still enough antibodies that bind to other sites in that portion of the molecular to still neutralize the virus.
both shots. I am not looking forward to going through that again with this one. I'll have to plan on being in bed the whole next day after this vaccine. Hope for a better experience.
Hey US1, I work in a rehab hospital. The majority of us have gotten the first Covid vaccine shot already. Everyone that also had the Shingrix shot said that it was much worse than the Covid vaccine. I haven't gotten the shingles shot myself, but seems to be a rough one. But compared to the pain that comes with shingles it was probably worth it
From my understanding, the problem with the Shingrix vaccine is the additional stuff in the shot, called and adjuvant. The adjuvant is designed to amp up the immune response to the vaccine and the inflammation can be painful. That adjuvant is not (to my knowledge) present in the COVID vaccines so those should not be as bad.
I have a question. Does this vaccine address the two additional or any future strains of COVID?
So far, it looks like the vaccines will work against the mutated strains. I believe it's because the vaccine targets the spike protein the virus uses to invade human cells, and these new strains have little or no mutation to that protein. Pfizer Covid vaccine ‘works against two new mutant strains’ - ( New Window )
Well, it actually has several mutations in the spike, including a deletion. IIRC only one mutation in the part of the spike which interacts with the host cell and so, it looks like there are still enough antibodies that bind to other sites in that portion of the molecular to still neutralize the virus.
I was in the very first wave to get it because I'm an anesthesiologist, and I've intubated lots of COVID patients. It feels so much better to know I'm protected!
I am long time giants fan and frequent lurker who has never posted before, but feel motivated to give my 2cents on this issue
I am a front line COVID-19 provider. I am a hospital based physician and work in a southern San Diego (actually Chula Vista for those familiar with area) hospital directly caring for hospitalized COVID-19 patients. I cared for our hospital's first covid patient back in March 2020 and have cared for 100's of COVID-19 patients since that time. At present, we are completely overwhelmed with COVID-19 patients. It is much much worse than our first wave. We are continuously transitioning more and more regular floors to covid units and presently about 2/3 -3/4 of our total patient census is COVID. Our ICU is at capacity and at present, we have numerous patients on regular covid floors whose clinical condition easily warrant ICU management/intubation. We have to carefully decide who gets ventilators, high flow units, and bipaps due to shortages/ none available. Yesterday, I cared for a man who is on 100% 02 on bipap with po2 level of 44 (in simple terms -life threatening hypoxemia) who remains on floor, due to lack of ICU beds and ventilators. My point is that the situation here is beyond critical.
Do I have worries about the long term effects of vaccine? Sure, but not near the worry I have about the long term effects of covid on our health (both physical and emotional), economy, and our way of life. I am not willing to continue living like this for next several years waiting for definitive evidence that there are no dangerous long term vaccine risks. Others may be willing to wait but I don't think they are willing to continue to live like this. Frankly, I believe they are counting on herd immunity (from others taking the vaccine) to protect themselves. To me, this is very a cynical and selfish attitude. If we all did this, the pandemic might never end. Risks and sacrifices need to be made to get through this. I see fellow physicians, nurses and respiratory therapists doing so every day. I feel that the vaccine is our only quick and effective way out of this disaster. People who won't take the vaccine are not helping to solve the crisis for their families, communities, the country and the world.
With all that being said, of course, I strongly believe everyone has the right to do what they want and no one should ever be forced to take the vaccine unwillingly.
Just my opinion, take it or leave it as you wish.
I just received my second vaccine dose yesterday (Pfizer). After the first dose, I had sore arm and felt lethargic the next day. Today, one day after 2nd dose, my arm is a little sore, but otherwise I feel great.
Isn't the goal of the vaccine to provide herd immunity?
Unfortunately everything I have read is there is no certainty around the vaccines released so far either a) preventing you from getting COVID and b) spreading it to others.
Here is a quote from a WSJ published today:
Quote:
Do the Covid vaccines prevent you from spreading the virus, or do they just protect you from getting sick?
Scientists don’t know yet—and the uncertainty has big implications during the rollout of the vaccines....
Also, a Lancet article from last week (linked) that talks about how logistically a global immunization event like this has never been done and there are many unknowns due to the increased testing cycle.
Even if the vaccine is 95% effective, the bulk of the healthy, non-elderly, population probably has less than a 5% chance of being infected, a lower percent chance of being hospitalized and even lower of dying.
I think that's partly why we are seeing such slow adoption rates.
In the past week I have lost both god parents (my Aunt and Uncle - married 53 years died a few days apart) to COVID, and IMO that is the population we should be aggressively vaccinating (the elderly, group/LTC home residents, front line medical staff, and people with potential co-morbities like obesity, diabetes, respiratory illnesses) but it seems like the focus is in the wrong place.
Are you seeing colleagues reject the vaccine?
Are you seeing or hearing about a lot of no-shows for the vaccine (NY is reporting a ton).
IMO that is the population we should be aggressively vaccinating (the elderly, group/LTC home residents, front line medical staff, and people with potential co-morbities like obesity, diabetes, respiratory illnesses) but it seems like the focus is in the wrong place.
PJ - I agree with that focus, but what other groups are being targeted that shouldn't be?
And yes I have read a large number of heath care workers not wanting the vaccine, for a variety of reasons, including political and scientific.
RE: RE: bcinsd thank your for your front line support
IMO that is the population we should be aggressively vaccinating (the elderly, group/LTC home residents, front line medical staff, and people with potential co-morbities like obesity, diabetes, respiratory illnesses) but it seems like the focus is in the wrong place.
PJ - I agree with that focus, but what other groups are being targeted that shouldn't be?
And yes I have read a large number of heath care workers not wanting the vaccine, for a variety of reasons, including political and scientific.
Every state is different.
In MA 75+year old people are in phase 2 as are people with 2 or more potential co-morbidities.
Same in NY, the elderly are in phase 2 or 3 after groups that IMO were less risky. I read in NY a fraction of the identified people were actually taking the vaccine AND the guidelines about who could get it were so inflexible and included massive fines for deviating from the guidelines some doses were wasted. Because of this they have adjusted the guidelines.
I am far from a vaccine logistics expert, but when I look at every COVID death and hospitalization chart I don't see how you wouldn't start with the people actually dying the most, the over 75 crowd. Just seems pretty obvious to me.
in MA (where I live) general population isn't even really eligible until Spring/Summer (April - June) so while long-term effects likely won't be known I'd be surprised if there isn't good data on efficacy and obviously short-term effects will be well documented.
My father (who lives in FL) got the Moderna vaccine initial dose and reported no side effects.
I pray the rest of country doesn't get hit as hard by second wave as we are.
Certainly herd immunity is the goal. Its about how we get there. For every person who delays taking the vaccine it takes us that much longer to get there. Some march to the battle field to destroy the enemy, others lag behind depending on the sacrifice of others to assure their safety.
Although the death rate from COVID is low, remember that if even 1% die and 80% of Americans eventually get it (a guess, but this virus is so contagious, I think that number might be low), thats still millions of Americans dead (and imagine around the world!).
The vaccine works. Plain and simple. It can save so many lives and can get us back to near normalcy quickly.
Almost every health care provider I know has eagerly awaited the vaccine. Only one doctor I know has said no and for the same Guinea pig logic that is so common.
I don't have strong opinion on rollout and qualifying criteria because I think everyone needs to get vaccinated ASAP. Just giving it to old people and skipping healthy people allow the virus spread to continue. People need to stop dying and we need to get our society back to normal.
I am hopeful the incoming administration "gets it" and within a few months we will see a huge increase in availably of vaccine. Then it'll be up to the healthy population to step up, take the vaccine, and turn the tide on the pandemic.
also living in MA, so I won't be able to get the vaccine until April probably, but you can be damn sure I will be getting it ASAP as soon as I am eligible. My wife is a healthcare provider (though not frontline), so she will probably be getting it before me. We are both ready to do our part to end this horrible pandemic and start rebuilding.
The whole country of Norway I believe only had 500 COVID deaths.
Quote:
Twenty-three people died in Norway within days of receiving their first dose of the Pfizer COVID-19 vaccine, with 13 of those deaths — all nursing home patients — apparently related to the side effects of the shots, health officials said....
and none of them had any bad reaction other than a sore arm the next day.
I didn't realize that. Since you personally know several people who didn't have an issue I guess it must be safe for everyone. I'll let the families of those 23 dead people know that US1 Giants disagrees their loved ones are dead because he knows several people who didn't have an issue.
Let me see if I can sign my father up for the vaccine now that I feel so confident and reassured.
Thank you!
RE: RE: I know serveral senior citizens who received the Pfizer vaccine
and none of them had any bad reaction other than a sore arm the next day.
I didn't realize that. Since you personally know several people who didn't have an issue I guess it must be safe for everyone. I'll let the families of those 23 dead people know that US1 Giants disagrees their loved ones are dead because he knows several people who didn't have an issue.
Let me see if I can sign my father up for the vaccine now that I feel so confident and reassured.
Thank you!
I was in a zoom conference on vaccines today and Norway was brought up. It’s not clear whether or not it was a specific vaccine issue considering the frailty of the people vaccinated. It should give you pause but not stop you in your tracks. There’s a lot of safety data and it’s all positive, so Norway requires a lot of investigation before concluding anything negative about the vaccine.
Isn't the goal of the vaccine to provide herd immunity?
Unfortunately everything I have read is there is no certainty around the vaccines released so far either a) preventing you from getting COVID and b) spreading it to others.
Yes. Probably looking at something more like the flu than polio, at least initially. Minimize number of and severity of infections.
Quote:
Even if the vaccine is 95% effective, the bulk of the healthy, non-elderly, population probably has less than a 5% chance of being infected, a lower percent chance of being hospitalized and even lower of dying.
Those odds are way off. There are areas of the country that's already have >20% of the population infected.
Quote:
In the past week I have lost both god parents (my Aunt and Uncle - married 53 years died a few days apart) to COVID, and IMO that is the population we should be aggressively vaccinating (the elderly, group/LTC home residents, front line medical staff, and people with potential co-morbities like obesity, diabetes, respiratory illnesses) but it seems like the focus is in the wrong place.
As with most things, it was left to the states. The CDC recommended that LTC and front-line workers go first. The worst part of it is none of this seems to be verified, so people are signing up and saying they meet the requirements.
Patience is required. Even after taking the vaccine, you'll still need to wear masks, wash hands, and social distance until we know more about the risk of vaccinated people being able to still spread the virus.
From NPR, January 12th:
Quote:
Can I spread the virus to others even if I'm fully vaccinated?
This is an important question, but scientists studying the shots' effectiveness don't have an answer yet. And for public health experts, that lack of knowledge means you should act like the answer is yes.
Here's why: Before approving the Moderna and Pfizer vaccines, the FDA asked the vaccine manufacturers only whether their products protect people from COVID-19 symptoms. They didn't ask if the vaccines stop people who've been vaccinated from nevertheless spreading the virus to others. The emergency authorizations by the FDA that have allowed distribution of the two new vaccines cite only their ability to keep you — the person vaccinated — from becoming severely sick with COVID-19.
In the words of the Centers for Disease Control and Prevention, "Experts need to understand more about the protection that COVID-19 vaccines provide before deciding to change recommendations on steps everyone should take to slow the spread of the virus that causes COVID-19."
The data to answer the question of whether vaccinated people can still spread the virus are just now being collected.
both shots. I am not looking forward to going through that again with this one. I'll have to plan on being in bed the whole next day after this vaccine. Hope for a better experience.
Me too! The Shingrix was nasty. I just had my second shot this week. It knocked me on my ass and gave me the first fever I've had in 28 years. The first shot sent me to the ER. On the other hand my 80+ year old parents got the Moderna vaccine this week and had nothing but sore arms for about an hour.
It advises that people still need to wear a mask, observe social distancing, and avoid crowds after receiving the vaccine. Had not heard this previously.
It advises that people still need to wear a mask, observe social distancing, and avoid crowds after receiving the vaccine. Had not heard this previously. You Should Still Wear A Mask And Avoid Crowds After Getting The COVID-19 Vaccine - ( New Window )
Not surprising. You can still get the flu even with a flu shot. So until a large part of the populace gets the vaccine you can still spread COVID as if you were asymptomatic I suppose.
both shots. I am not looking forward to going through that again with this one. I'll have to plan on being in bed the whole next day after this vaccine. Hope for a better experience.
Me too! The Shingrix was nasty. I just had my second shot this week. It knocked me on my ass and gave me the first fever I've had in 28 years. The first shot sent me to the ER. On the other hand my 80+ year old parents got the Moderna vaccine this week and had nothing but sore arms for about an hour.
I said this before, but I’ll repeat. Not all vaccines are the same so you can’t say that because one affected you a different also will. Shingrix contains an adjuvant, which is *additional* to the varicella meant to stimulate immunity. That additive, is an accessory that causes inflammation to better draw immune cells to the injection site to respond to the varicella. That’s what kicked your ass. None of the COVID vaccines contain that additive, so it shouldn’t cause that same response.
It advises that people still need to wear a mask, observe social distancing, and avoid crowds after receiving the vaccine. Had not heard this previously. You Should Still Wear A Mask And Avoid Crowds After Getting The COVID-19 Vaccine - ( New Window )
Not surprising. You can still get the flu even with a flu shot. So until a large part of the populace gets the vaccine you can still spread COVID as if you were asymptomatic I suppose.
In primates the vaccines cleared virus from the lungs (protects) but wasn’t great at removing it from the nasal passages\upper respiratory tract which is where transmission comes from. But, you’re still immune so I would guess that the if you do transmit to any extent, the amount and duration would be more limited. BUt more studies need to be done. They’re are investigating intranasal delivery (think Flonase) and that seems to clear the upper respiratory tract.
It advises that people still need to wear a mask, observe social distancing, and avoid crowds after receiving the vaccine. Had not heard this previously. You Should Still Wear A Mask And Avoid Crowds After Getting The COVID-19 Vaccine - ( New Window )
Not surprising. You can still get the flu even with a flu shot. So until a large part of the populace gets the vaccine you can still spread COVID as if you were asymptomatic I suppose.
In primates the vaccines cleared virus from the lungs (protects) but wasn’t great at removing it from the nasal passages\upper respiratory tract which is where transmission comes from. But, you’re still immune so I would guess that the if you do transmit to any extent, the amount and duration would be more limited. BUt more studies need to be done. They’re are investigating intranasal delivery (think Flonase) and that seems to clear the upper respiratory tract.
Will this be the primary deliver system or an adjunct?
I get the flu shot each fall. And while it's not 100% effective in preventing you from getting the flu, I believe it means that, if you do get it, your symptoms won't be as severe.
I've had the flu twice. I wouldn't wish this upon my worst enemy.
It advises that people still need to wear a mask, observe social distancing, and avoid crowds after receiving the vaccine. Had not heard this previously. You Should Still Wear A Mask And Avoid Crowds After Getting The COVID-19 Vaccine - ( New Window )
Not surprising. You can still get the flu even with a flu shot. So until a large part of the populace gets the vaccine you can still spread COVID as if you were asymptomatic I suppose.
In primates the vaccines cleared virus from the lungs (protects) but wasn’t great at removing it from the nasal passages\upper respiratory tract which is where transmission comes from. But, you’re still immune so I would guess that the if you do transmit to any extent, the amount and duration would be more limited. BUt more studies need to be done. They’re are investigating intranasal delivery (think Flonase) and that seems to clear the upper respiratory tract.
Will this be the primary deliver system or an adjunct?
They’re a ways away so my guess would be intramuscular will be entrenched. And, there’s still no proof that people transmit after an IM vaccination.
RE: RE: I know serveral senior citizens who received the Pfizer vaccine
and none of them had any bad reaction other than a sore arm the next day.
I didn't realize that. Since you personally know several people who didn't have an issue I guess it must be safe for everyone. I'll let the families of those 23 dead people know that US1 Giants disagrees their loved ones are dead because he knows several people who didn't have an issue.
Let me see if I can sign my father up for the vaccine now that I feel so confident and reassured.
Thank you!
This seems to me like an overly strong and obnoxious reply to someone sharing (though 2nd hand) experience with the vaccine in a thread full of people sharing experiences. I mean, you yourself just posted about your father getting his first dose without side effects (which also makes your last sentence here even more strange).
No one here is claiming or even implying that the vaccine is 100% safe for everyone.
I get my 2nd dose on Thursday. Heard the second one is worse.
Side bar, not sure why but I posted after I got vaccinated and the post was deleted almost immediately.
God bless her.
Worth getting vaccine if I had it already?
Wife just got her 2nd Pfizer shot today
Little bit of a sore arm, tingling , itchy throat for a little
But nothing worth noting
My hope is end of March in California
Wishful thinking?
Jackson Memorial opened up to over 65 last Tuesday.
I clicked on the site and scheduled an appt for the following day.
I got there a half hour early and they were running ahead of schedule so they took me.
It was a smooth process and took about a half an hour start to finish.
The last thing they do is make you wait 15 minutes before you leave.
I have not had any after effects.
Good luck with yours!
If going back in three weeks - Pfizer
If going back in 4 weeks - Moderna
And chiro take your bullshit somewhere else
Yeah, Shingrix made me a little punky the next day and arm sore three days. Worse 2nd shot then 1st. Took and Advil at felt better in an hour and a half.
Exactly, huge no thanks for me. Rushed vaccine, no animal trials, total violation of Nuremberg codes. Really hope the best for all you that have elected to get it and hope it works, but I’m not going to be a human guinea pig.
And chiro take your bullshit somewhere else
Ha, I'm 4 months short of 65 and the calculator says I am # 17.4 mill in FL with a Population of 22 mill and like 268 mill in the US...
Link - ( New Window )
That’s just speculation on your part. There’s nothing to indicate that. The vaccine has a short half life and does not persist in your system.
Quote:
M-RNA vaccine is a new and different vaccine.
Exactly, huge no thanks for me. Rushed vaccine, no animal trials, total violation of Nuremberg codes. Really hope the best for all you that have elected to get it and hope it works, but I’m not going to be a human guinea pig.
Geezus. It is using known technology that has been around 15 or 20 years. That is why it was developed so fast.
Good the more idiots that don't get it means those that want it get t sooner.
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
Actually there were animal trials. Furthermore there has been quite a bit of work with this type of vaccine (mRNA, Coronavirus, Ab vs the spike protein). This allowed rapid preclinical development. Was it rushed? Heck yeah!
Nuremburg codes? You've got to be kidding. I would think the results with 95% efficacy and excellent safety would be affirming on that one.
I will grant that there is some uncertainty about long-term safety, but the risk is quite small and is mostly used as an excuse by people who want to scare others or are so distrustful of medicine that they will use that as their excuse. You don't have to trust anybody and you don't have to get a vaccine, but all the experts including the independent panel that reviewed the data were all supportive.
In comment 15117913 beatrixkiddo said:
Quote:
M-RNA vaccine is a new and different vaccine.
Exactly, huge no thanks for me. Rushed vaccine, no animal trials, total violation of Nuremberg codes. Really hope the best for all you that have elected to get it and hope it works, but I’m not going to be a human guinea pig.
Actually there were animal trials. Furthermore there has been quite a bit of work with this type of vaccine (mRNA, Coronavirus, Ab vs the spike protein). This allowed rapid preclinical development. Was it rushed? Heck yeah!
Nuremburg codes? You've got to be kidding. I would think the results with 95% efficacy and excellent safety would be affirming on that one.
I will grant that there is some uncertainty about long-term safety, but the risk is quite small and is mostly used as an excuse by people who want to scare others or are so distrustful of medicine that they will use that as their excuse. You don't have to trust anybody and you don't have to get a vaccine, but all the experts including the independent panel that reviewed the data were all supportive.
In comment 15117913 beatrixkiddo said:
Quote:
M-RNA vaccine is a new and different vaccine.
Exactly, huge no thanks for me. Rushed vaccine, no animal trials, total violation of Nuremberg codes. Really hope the best for all you that have elected to get it and hope it works, but I’m not going to be a human guinea pig.
I'll wait.
Actually there were animal trials. Furthermore there has been quite a bit of work with this type of vaccine (mRNA, Coronavirus, Ab vs the spike protein). This allowed rapid preclinical development. Was it rushed? Heck yeah!
Nuremburg codes? You've got to be kidding. I would think the results with 95% efficacy and excellent safety would be affirming on that one.
I will grant that there is some uncertainty about long-term safety, but the risk is quite small and is mostly used as an excuse by people who want to scare others or are so distrustful of medicine that they will use that as their excuse. You don't have to trust anybody and you don't have to get a vaccine, but all the experts including the independent panel that reviewed the data were all supportive.
Thank you Bob...anti-vaxxers are a public safety hazard
Quote:
With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
What other vaccine trial had people lining up to volunteer by the droves? Do you know how hard it is to get 40,000 volunteers to take an experimental vaccine? For the Covid vaccine, it was so highly publicized that people were lining up and it took weeks to get the 40,000 as opposed to month, years....
I do clinical research for a living (altho not for vaccines) and the clinical trial results were quite good and very transparent. I read the entire Pfizer briefing book for the FDA Ad Board mtg and much of the Moderna one. The data was very impressive
In comment 15117941 beatrixkiddo said:
Quote:
With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
I do clinical research for a living (altho not for vaccines) and the clinical trial results were quite good and very transparent. I read the entire Pfizer briefing book for the FDA Ad Board mtg and much of the Moderna one. The data was very impressive
In comment 15117941 beatrixkiddo said:
Quote:
In comment 15117920 oghwga said:
Quote:
With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
Let's see the snappy come backs from chiro and beatrix on that....
In comment 15117928 Jim in Fairfax said:
Quote:
M-RNA vaccine is a new and different vaccine.
That’s just speculation on your part. There’s nothing to indicate that. The vaccine has a short half life and does not persist in your system.
Quote:
Actually the guinea pigs were the close to 100,000 people who volunteered for the trials. Some of those people were randomized to placebo and haven't gotten vaccinated yet. The preclinical part was really fast because a lot of work had already been done with prior coronaviruses and RNA viruses. The clinical trials went fast because everything was expedited by everyone for obvious reasons and there were so f'in' many people who got infected.
I do clinical research for a living (altho not for vaccines) and the clinical trial results were quite good and very transparent. I read the entire Pfizer briefing book for the FDA Ad Board mtg and much of the Moderna one. The data was very impressive
In comment 15117941 beatrixkiddo said:
Quote:
In comment 15117920 oghwga said:
Quote:
With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
Let's see the snappy come backs from chiro and beatrix on that....
@section125 - I don’t post to get into pissing matches and flex my keyboard muscles with people here. So why don’t you temper your hostilities.
@ Bob - again no long term side effects have been conducted, projection is merely that, projection. Doing this on a large scale is incredibly risky IMO. Of course big pharma is going to right glowing reviews on a product they produce that will make them billions. Horrible side effects,no worries they have been granted blanket legal immunity. Get sick from taking the shot, great you can take their next solution to fix you up on the crap they made you sick with. Win-win. The regulatory agencies (FDA, etc.) are horse shit, these people on these boards all come from the pharmaceutical companies they are now supposed to regulate, That doesn’t worry you? Ok.
Worth getting vaccine if I had it already?
Wife just got her 2nd Pfizer shot today
Little bit of a sore arm, tingling , itchy throat for a little
But nothing worth noting
@section125 - I don’t post to get into pissing matches and flex my keyboard muscles with people here. So why don’t you temper your hostilities.
@ Bob - again no long term side effects have been conducted, projection is merely that, projection. Doing this on a large scale is incredibly risky IMO. Of course big pharma is going to right glowing reviews on a product they produce that will make them billions. Horrible side effects,no worries they have been granted blanket legal immunity. Get sick from taking the shot, great you can take their next solution to fix you up on the crap they made you sick with. Win-win. The regulatory agencies (FDA, etc.) are horse shit, these people on these boards all come from the pharmaceutical companies they are now supposed to regulate, That doesn’t worry you? Ok.
This isn't twitter there is no "@" needed.
Ok so you come on here dealing ignorant shit, so who is being hostile.
If you don't want the shot, that is up to you, but don't go spreading falsehoods.
You of course are wrong that all the people on independent panels are from pharma companies, they're mostly from academia. There are super-strict rules about disclosure of payment to physicians, and if you get caught mis-representing you can go to jail.
The people from FDA drive me crazy sometimes, but they are competent, not paid very well, and are stuck between complaints about approving things too quickly and too slowly, both due to public pressure.
I was an academic physician who went into pharma. Did I compromise my morals by doing so? My friend thinks so, but there are so many rules and the penalties for mis-representing data are super-severe (if Pfizer was caught mis-representing data their stock would plummet), so if anything I think most companies are if anything overly cautious. Some are not, some of them get caught and I'm sure there are some who don't.
The long-term safety is certainly unknown since there hasn't been time to study it. But the risk is extremely low, which is why the vaccines were approved.
"Very risky" is untrue. But a little risky, OK. Risker than getting Covid? No. I don't agree with giving the companies legal immunity, if that happened I don't agree with it. In the movies these pharma companies are always depicted as having these diabolical criminals (loved the Fugitive, btw). That's not really how things work.
In comment 15117989 beatrixkiddo said:
Quote:
In comment 15117955 Bob from Massachusetts said:
Quote:
Actually the guinea pigs were the close to 100,000 people who volunteered for the trials. Some of those people were randomized to placebo and haven't gotten vaccinated yet. The preclinical part was really fast because a lot of work had already been done with prior coronaviruses and RNA viruses. The clinical trials went fast because everything was expedited by everyone for obvious reasons and there were so f'in' many people who got infected.
I do clinical research for a living (altho not for vaccines) and the clinical trial results were quite good and very transparent. I read the entire Pfizer briefing book for the FDA Ad Board mtg and much of the Moderna one. The data was very impressive
In comment 15117941 beatrixkiddo said:
Quote:
In comment 15117920 oghwga said:
Quote:
With your fake facebook need Nuremberg codes bullshit. God damnit I'm starting to hate america and it's lack of critical thinking ability
Haha. Man I’m dying here laughing at how much irony there is in your rant. Usually takes 10years minimum to develop a normalvaccine safely Fact. Rushed vaccinne that uses experimental never before tested technology, check. Skips animal trials and normal safety checks , check. You can be a Human guinea pig, but not sure why your mad at me for just stating the truth.
Let's see the snappy come backs from chiro and beatrix on that....
@section125 - I don’t post to get into pissing matches and flex my keyboard muscles with people here. So why don’t you temper your hostilities.
@ Bob - again no long term side effects have been conducted, projection is merely that, projection. Doing this on a large scale is incredibly risky IMO. Of course big pharma is going to right glowing reviews on a product they produce that will make them billions. Horrible side effects,no worries they have been granted blanket legal immunity. Get sick from taking the shot, great you can take their next solution to fix you up on the crap they made you sick with. Win-win. The regulatory agencies (FDA, etc.) are horse shit, these people on these boards all come from the pharmaceutical companies they are now supposed to regulate, That doesn’t worry you? Ok.
Some people I work with were ill in bed for a couple of days.
Some people I work with were ill in bed for a couple of days.
All from Pfizer
Link below.
It was beaten into the public that a vaccine would take "at least" 18 months to 2 years by multiple experts and as noted in the fact check link below, it would take a miracle to have one before the end of 2020.
Well, here we are.
So, sure, maybe it's totally safe, who knows. But when the experts told you all summer it would need a miracle and that miracle actually happens, it's fine to be careful about ingesting the substance that was the fruit of that miracle.
No need to shame or bully someone who isn't willing to suddenly trust "experts" who have been all over the map on this thing. Experts of all parties and persuasions.
Here are some quotes:
This was May 15th (and just one article)
“In the best of circumstances, we should have a vaccine — or let's say vaccines — between 12 and 18 months," he said. "Whether those circumstances will be the best or not, we don’t know."...
All these experts skeptical, and some guy is apprehensive about taking it and he's getting bullied and shamed on here.
GTFO.
Also, in CA almost 40% of front line healthcare workers have rejected the vaccine? Why? They cite both the relative low risk of COVID for their age group and the unknown effects of a miracle vaccine.
Take the vaccine if you want, though I think it should be given first to the people dying (the over 70 year olds or those with the co-morbities - obesity, diabetes, etc.), but don't shame people for being cautious about it.
link - ( New Window )
Gonna breathe easier from afar once she is fully vaccinated. Major badass, she is. Said “this is my calling and if it ends it for me, it ends it.”
Really never not amazed by her.
I hate it. It's why people don't wear masks and don't take things seriously and cherry pick their facts so they can feel like they have power over something.
I've had people tell me that Fauci should be in jail that bill gates and big pharma created the virus that masks cause syndromes worse than the disease that covid isn't all that bad I am sick and tired of all the nitwitteey I encounter on a daily basis.
I am not a smart man. I don't double down by insisting that I am smarter than Dr Fauci to make myself feel better.
Social media users are constantly bombarded by nonsense and they slurp it up and here we are a year later worse than when we started and people are pissed that they have to wear masks and can't go to bars and they demand service at establishments while not wearing a mask because they think it violates their rights.
I am done being civil to people that spread stupidity.
Sorry.
Check my history. I never argue with anyone here. I am just exhausted by the smugness I see on the self satisfied people who walk around maskless because their Facebook news feed told them not to be sheeple.
All these experts skeptical, and some guy is apprehensive about taking it and he's getting bullied and shamed on here.
GTFO.
If someone is apprehensive and wants to pass, fine. He’s pushing falsehoods about it.
How They Made a Vaccine So Fast - ( New Window )
And anyway, I was mostly referring to the hesitance to take the vaccine due to the speed it was brought to market, not whatever falsehoods may have been sent and I'm pretty sure no one was influenced by the falsehoods.
There were some generic studies indicating some susceptibility to ADE but Not specific to the discussed vaccines.
first shot cause arm pain cleared up in a day
second shot he felt like he was getting the flu
feeling very ill he went to bed very early that day
slept a very long night and woke up feeling better
he said every medical person he works with felt the same way after taking second shot .
Quote:
Please tell me the long term effects of the virus....
There were some generic studies indicating some susceptibility to ADE but Not specific to the discussed vaccines.
There was some suggestion about ADE with the original SARS, due to everyone having antibodies to one or more of the other 4 common seasonal coronaviruses, but I am not sure those studies have held up. Based on that, there was an early fear that ADE might be something to worry about with about CoV-2, but that has proven to be unfounded. There is actually little to no reactivity of antibodies with the seasonal coronaviruses and COV-2 (and vice versa). WRT vaccine, ADE should likewise not be an issue but it is worth watching the response of people who already have had COVID to the vaccine(I'm betting it's a boosted response rather than a pathological one).
One the rapidity of the vaccine relative to others, consider that most vaccines are not money makers and usually it's a company or two with a couple of scientists on the project toiling away in a vacuum for several years. With COVID, it's pretty much every scientist on the planet working in concert night and day and examining multiple per-established platforms.
And, whatever the vaccine, there absolutely were animal studies, including NHP studies.
And, the people reviewing the data prior to approval were largely academicians who were not on any company's payroll.
And, we've got data on nearly 100K people on all the vaccines. Both safety and efficacy.
So far, the vaccines are believed to be protective against the new strains. There is some suggestion that at least one of the new strains (South Africa) *might* escape from one of the monoclonal antibody therapeutics.
So far, it looks like the vaccines will work against the mutated strains. I believe it's because the vaccine targets the spike protein the virus uses to invade human cells, and these new strains have little or no mutation to that protein.
Pfizer Covid vaccine ‘works against two new mutant strains’ - ( New Window )
Hey US1, I work in a rehab hospital. The majority of us have gotten the first Covid vaccine shot already. Everyone that also had the Shingrix shot said that it was much worse than the Covid vaccine. I haven't gotten the shingles shot myself, but seems to be a rough one. But compared to the pain that comes with shingles it was probably worth it
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I have a question. Does this vaccine address the two additional or any future strains of COVID?
So far, it looks like the vaccines will work against the mutated strains. I believe it's because the vaccine targets the spike protein the virus uses to invade human cells, and these new strains have little or no mutation to that protein. Pfizer Covid vaccine ‘works against two new mutant strains’ - ( New Window )
Well, it actually has several mutations in the spike, including a deletion. IIRC only one mutation in the part of the spike which interacts with the host cell and so, it looks like there are still enough antibodies that bind to other sites in that portion of the molecular to still neutralize the virus.
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both shots. I am not looking forward to going through that again with this one. I'll have to plan on being in bed the whole next day after this vaccine. Hope for a better experience.
Hey US1, I work in a rehab hospital. The majority of us have gotten the first Covid vaccine shot already. Everyone that also had the Shingrix shot said that it was much worse than the Covid vaccine. I haven't gotten the shingles shot myself, but seems to be a rough one. But compared to the pain that comes with shingles it was probably worth it
From my understanding, the problem with the Shingrix vaccine is the additional stuff in the shot, called and adjuvant. The adjuvant is designed to amp up the immune response to the vaccine and the inflammation can be painful. That adjuvant is not (to my knowledge) present in the COVID vaccines so those should not be as bad.
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In comment 15118348 GFiLA said:
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I have a question. Does this vaccine address the two additional or any future strains of COVID?
So far, it looks like the vaccines will work against the mutated strains. I believe it's because the vaccine targets the spike protein the virus uses to invade human cells, and these new strains have little or no mutation to that protein. Pfizer Covid vaccine ‘works against two new mutant strains’ - ( New Window )
Well, it actually has several mutations in the spike, including a deletion. IIRC only one mutation in the part of the spike which interacts with the host cell and so, it looks like there are still enough antibodies that bind to other sites in that portion of the molecular to still neutralize the virus.
Thanks for the clarification.
I am a front line COVID-19 provider. I am a hospital based physician and work in a southern San Diego (actually Chula Vista for those familiar with area) hospital directly caring for hospitalized COVID-19 patients. I cared for our hospital's first covid patient back in March 2020 and have cared for 100's of COVID-19 patients since that time. At present, we are completely overwhelmed with COVID-19 patients. It is much much worse than our first wave. We are continuously transitioning more and more regular floors to covid units and presently about 2/3 -3/4 of our total patient census is COVID. Our ICU is at capacity and at present, we have numerous patients on regular covid floors whose clinical condition easily warrant ICU management/intubation. We have to carefully decide who gets ventilators, high flow units, and bipaps due to shortages/ none available. Yesterday, I cared for a man who is on 100% 02 on bipap with po2 level of 44 (in simple terms -life threatening hypoxemia) who remains on floor, due to lack of ICU beds and ventilators. My point is that the situation here is beyond critical.
Do I have worries about the long term effects of vaccine? Sure, but not near the worry I have about the long term effects of covid on our health (both physical and emotional), economy, and our way of life. I am not willing to continue living like this for next several years waiting for definitive evidence that there are no dangerous long term vaccine risks. Others may be willing to wait but I don't think they are willing to continue to live like this. Frankly, I believe they are counting on herd immunity (from others taking the vaccine) to protect themselves. To me, this is very a cynical and selfish attitude. If we all did this, the pandemic might never end. Risks and sacrifices need to be made to get through this. I see fellow physicians, nurses and respiratory therapists doing so every day. I feel that the vaccine is our only quick and effective way out of this disaster. People who won't take the vaccine are not helping to solve the crisis for their families, communities, the country and the world.
With all that being said, of course, I strongly believe everyone has the right to do what they want and no one should ever be forced to take the vaccine unwillingly.
Just my opinion, take it or leave it as you wish.
I just received my second vaccine dose yesterday (Pfizer). After the first dose, I had sore arm and felt lethargic the next day. Today, one day after 2nd dose, my arm is a little sore, but otherwise I feel great.
Am I a bit skeptical, sure. The FDA has made mistakes in approvals of past drugs, it happens.
But in this case I am more apt to take it considering the impact of the virus.
Isn't the goal of the vaccine to provide herd immunity?
Unfortunately everything I have read is there is no certainty around the vaccines released so far either a) preventing you from getting COVID and b) spreading it to others.
Here is a quote from a WSJ published today:
Scientists don’t know yet—and the uncertainty has big implications during the rollout of the vaccines....
Also, a Lancet article from last week (linked) that talks about how logistically a global immunization event like this has never been done and there are many unknowns due to the increased testing cycle.
Even if the vaccine is 95% effective, the bulk of the healthy, non-elderly, population probably has less than a 5% chance of being infected, a lower percent chance of being hospitalized and even lower of dying.
I think that's partly why we are seeing such slow adoption rates.
In the past week I have lost both god parents (my Aunt and Uncle - married 53 years died a few days apart) to COVID, and IMO that is the population we should be aggressively vaccinating (the elderly, group/LTC home residents, front line medical staff, and people with potential co-morbities like obesity, diabetes, respiratory illnesses) but it seems like the focus is in the wrong place.
Are you seeing colleagues reject the vaccine?
Are you seeing or hearing about a lot of no-shows for the vaccine (NY is reporting a ton).
Thanks again.
Lancet Article Link - ( New Window )
PJ - I agree with that focus, but what other groups are being targeted that shouldn't be?
And yes I have read a large number of heath care workers not wanting the vaccine, for a variety of reasons, including political and scientific.
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IMO that is the population we should be aggressively vaccinating (the elderly, group/LTC home residents, front line medical staff, and people with potential co-morbities like obesity, diabetes, respiratory illnesses) but it seems like the focus is in the wrong place.
PJ - I agree with that focus, but what other groups are being targeted that shouldn't be?
And yes I have read a large number of heath care workers not wanting the vaccine, for a variety of reasons, including political and scientific.
Every state is different.
In MA 75+year old people are in phase 2 as are people with 2 or more potential co-morbidities.
Same in NY, the elderly are in phase 2 or 3 after groups that IMO were less risky. I read in NY a fraction of the identified people were actually taking the vaccine AND the guidelines about who could get it were so inflexible and included massive fines for deviating from the guidelines some doses were wasted. Because of this they have adjusted the guidelines.
I am far from a vaccine logistics expert, but when I look at every COVID death and hospitalization chart I don't see how you wouldn't start with the people actually dying the most, the over 75 crowd. Just seems pretty obvious to me.
My father (who lives in FL) got the Moderna vaccine initial dose and reported no side effects.
I haven't seen many working bullshit meters in years. Pretty fucking sad!
I pray the rest of country doesn't get hit as hard by second wave as we are.
Certainly herd immunity is the goal. Its about how we get there. For every person who delays taking the vaccine it takes us that much longer to get there. Some march to the battle field to destroy the enemy, others lag behind depending on the sacrifice of others to assure their safety.
Although the death rate from COVID is low, remember that if even 1% die and 80% of Americans eventually get it (a guess, but this virus is so contagious, I think that number might be low), thats still millions of Americans dead (and imagine around the world!).
The vaccine works. Plain and simple. It can save so many lives and can get us back to near normalcy quickly.
Almost every health care provider I know has eagerly awaited the vaccine. Only one doctor I know has said no and for the same Guinea pig logic that is so common.
I don't have strong opinion on rollout and qualifying criteria because I think everyone needs to get vaccinated ASAP. Just giving it to old people and skipping healthy people allow the virus spread to continue. People need to stop dying and we need to get our society back to normal.
I am hopeful the incoming administration "gets it" and within a few months we will see a huge increase in availably of vaccine. Then it'll be up to the healthy population to step up, take the vaccine, and turn the tide on the pandemic.
The whole country of Norway I believe only had 500 COVID deaths.
link - ( New Window )
I didn't realize that. Since you personally know several people who didn't have an issue I guess it must be safe for everyone. I'll let the families of those 23 dead people know that US1 Giants disagrees their loved ones are dead because he knows several people who didn't have an issue.
Let me see if I can sign my father up for the vaccine now that I feel so confident and reassured.
Thank you!
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and none of them had any bad reaction other than a sore arm the next day.
I didn't realize that. Since you personally know several people who didn't have an issue I guess it must be safe for everyone. I'll let the families of those 23 dead people know that US1 Giants disagrees their loved ones are dead because he knows several people who didn't have an issue.
Let me see if I can sign my father up for the vaccine now that I feel so confident and reassured.
Thank you!
I was in a zoom conference on vaccines today and Norway was brought up. It’s not clear whether or not it was a specific vaccine issue considering the frailty of the people vaccinated. It should give you pause but not stop you in your tracks. There’s a lot of safety data and it’s all positive, so Norway requires a lot of investigation before concluding anything negative about the vaccine.
Isn't the goal of the vaccine to provide herd immunity?
Unfortunately everything I have read is there is no certainty around the vaccines released so far either a) preventing you from getting COVID and b) spreading it to others.
Yes. Probably looking at something more like the flu than polio, at least initially. Minimize number of and severity of infections.
Even if the vaccine is 95% effective, the bulk of the healthy, non-elderly, population probably has less than a 5% chance of being infected, a lower percent chance of being hospitalized and even lower of dying.
Those odds are way off. There are areas of the country that's already have >20% of the population infected.
In the past week I have lost both god parents (my Aunt and Uncle - married 53 years died a few days apart) to COVID, and IMO that is the population we should be aggressively vaccinating (the elderly, group/LTC home residents, front line medical staff, and people with potential co-morbities like obesity, diabetes, respiratory illnesses) but it seems like the focus is in the wrong place.
As with most things, it was left to the states. The CDC recommended that LTC and front-line workers go first. The worst part of it is none of this seems to be verified, so people are signing up and saying they meet the requirements.
From NPR, January 12th:
This is an important question, but scientists studying the shots' effectiveness don't have an answer yet. And for public health experts, that lack of knowledge means you should act like the answer is yes.
Here's why: Before approving the Moderna and Pfizer vaccines, the FDA asked the vaccine manufacturers only whether their products protect people from COVID-19 symptoms. They didn't ask if the vaccines stop people who've been vaccinated from nevertheless spreading the virus to others. The emergency authorizations by the FDA that have allowed distribution of the two new vaccines cite only their ability to keep you — the person vaccinated — from becoming severely sick with COVID-19.
In the words of the Centers for Disease Control and Prevention, "Experts need to understand more about the protection that COVID-19 vaccines provide before deciding to change recommendations on steps everyone should take to slow the spread of the virus that causes COVID-19."
The data to answer the question of whether vaccinated people can still spread the virus are just now being collected.
Why You Should Still Wear A Mask And Avoid Crowds After Getting The COVID-19 Vaccine - ( New Window )
You Should Still Wear A Mask And Avoid Crowds After Getting The COVID-19 Vaccine - ( New Window )
Not surprising. You can still get the flu even with a flu shot. So until a large part of the populace gets the vaccine you can still spread COVID as if you were asymptomatic I suppose.
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both shots. I am not looking forward to going through that again with this one. I'll have to plan on being in bed the whole next day after this vaccine. Hope for a better experience.
Me too! The Shingrix was nasty. I just had my second shot this week. It knocked me on my ass and gave me the first fever I've had in 28 years. The first shot sent me to the ER. On the other hand my 80+ year old parents got the Moderna vaccine this week and had nothing but sore arms for about an hour.
I said this before, but I’ll repeat. Not all vaccines are the same so you can’t say that because one affected you a different also will. Shingrix contains an adjuvant, which is *additional* to the varicella meant to stimulate immunity. That additive, is an accessory that causes inflammation to better draw immune cells to the injection site to respond to the varicella. That’s what kicked your ass. None of the COVID vaccines contain that additive, so it shouldn’t cause that same response.
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It advises that people still need to wear a mask, observe social distancing, and avoid crowds after receiving the vaccine. Had not heard this previously. You Should Still Wear A Mask And Avoid Crowds After Getting The COVID-19 Vaccine - ( New Window )
Not surprising. You can still get the flu even with a flu shot. So until a large part of the populace gets the vaccine you can still spread COVID as if you were asymptomatic I suppose.
In primates the vaccines cleared virus from the lungs (protects) but wasn’t great at removing it from the nasal passages\upper respiratory tract which is where transmission comes from. But, you’re still immune so I would guess that the if you do transmit to any extent, the amount and duration would be more limited. BUt more studies need to be done. They’re are investigating intranasal delivery (think Flonase) and that seems to clear the upper respiratory tract.
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In comment 15123845 US1 Giants said:
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It advises that people still need to wear a mask, observe social distancing, and avoid crowds after receiving the vaccine. Had not heard this previously. You Should Still Wear A Mask And Avoid Crowds After Getting The COVID-19 Vaccine - ( New Window )
Not surprising. You can still get the flu even with a flu shot. So until a large part of the populace gets the vaccine you can still spread COVID as if you were asymptomatic I suppose.
In primates the vaccines cleared virus from the lungs (protects) but wasn’t great at removing it from the nasal passages\upper respiratory tract which is where transmission comes from. But, you’re still immune so I would guess that the if you do transmit to any extent, the amount and duration would be more limited. BUt more studies need to be done. They’re are investigating intranasal delivery (think Flonase) and that seems to clear the upper respiratory tract.
Will this be the primary deliver system or an adjunct?
I've had the flu twice. I wouldn't wish this upon my worst enemy.
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In comment 15123849 section125 said:
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In comment 15123845 US1 Giants said:
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It advises that people still need to wear a mask, observe social distancing, and avoid crowds after receiving the vaccine. Had not heard this previously. You Should Still Wear A Mask And Avoid Crowds After Getting The COVID-19 Vaccine - ( New Window )
Not surprising. You can still get the flu even with a flu shot. So until a large part of the populace gets the vaccine you can still spread COVID as if you were asymptomatic I suppose.
In primates the vaccines cleared virus from the lungs (protects) but wasn’t great at removing it from the nasal passages\upper respiratory tract which is where transmission comes from. But, you’re still immune so I would guess that the if you do transmit to any extent, the amount and duration would be more limited. BUt more studies need to be done. They’re are investigating intranasal delivery (think Flonase) and that seems to clear the upper respiratory tract.
Will this be the primary deliver system or an adjunct?
They’re a ways away so my guess would be intramuscular will be entrenched. And, there’s still no proof that people transmit after an IM vaccination.
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and none of them had any bad reaction other than a sore arm the next day.
I didn't realize that. Since you personally know several people who didn't have an issue I guess it must be safe for everyone. I'll let the families of those 23 dead people know that US1 Giants disagrees their loved ones are dead because he knows several people who didn't have an issue.
Let me see if I can sign my father up for the vaccine now that I feel so confident and reassured.
Thank you!
This seems to me like an overly strong and obnoxious reply to someone sharing (though 2nd hand) experience with the vaccine in a thread full of people sharing experiences. I mean, you yourself just posted about your father getting his first dose without side effects (which also makes your last sentence here even more strange).
No one here is claiming or even implying that the vaccine is 100% safe for everyone.