Both are nearly identical in terms of protection, in the 95% range. More importantly, just get whatever you can. Not a dig @ you, but I have friends who are passing on J&J because they want Moderna or Pfizer. I believe J&J is something like 66% effective, but still...it will limit you getting really sick if you do get COVID & that's the whole point of the vaccines...to reduce hospitalizations/deaths.
Pfizer’s effacy numbers are slightly better, but considering the way these are calculated, I’d say the difference is negligible. Side effects are basically the same and driven by individual immune system response based on age, health, allergy history and possibly even blood type. The only real benefit I see is the wait time between 1st and 2nd shots is 3 weeks for Pfizer vs 4 weeks for Moderna. But you are good to go with either one.
From what I understand, Moderna and Pfizer had similar efficacies after 1 shot, too. Mid-60%s. The second "booster" shot is what puts it over the top and into the mid-90%s.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
If you have a choice of which vaccine to get, and this includes the Janssen (J&J), get the one which you can have first.
This. In my family, we will have vaccine bingo.
My wife got Moderna. I have one shot of Pfizer and our oldest has one shot of Moderna. Two of the kids home from college this week are getting J&J one and done tomorrow. Our youngest gets Pfizer Thursday. It doesn't really matter which you get. Just get one. They're all extremely effective at reducing the impact of the virus.
Regarding the comparison of efficacy, it's important to note that these vaccines were tested individually for efficacy and not in a head to head comparison. That means they were tested at different times with different strains prevalent at the those times. Different populations and different locations. The results are not ideally suited for comparison as they were only intended to determine if they are effective at preventing infection and reducing the illness if infection occurs.
From what I understand, Moderna and Pfizer had similar efficacies after 1 shot, too. Mid-60%s. The second "booster" shot is what puts it over the top and into the mid-90%s.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
Pfizer and Moderna are similar vaccines that went through similar trials and came out with similar results. J&J is a different sort of vaccine and went through a different trial testing for different outcomes and had good results.
As someone has already said, you should probably take whichever one you can get first.
Yes the clinical efficacy of Pfizer and Moderna are higher but their Phase 3 trial was conducted during the late summer when COVID worldwide was at its lowest since April. Whereas J&J with it's lower efficacy was conducted mid winter during the highest period of worldwide COVID cases to date, AND with the rise of more contagious and severe variants.
Whos to say how the date would change if the clinical trial time periods were switched.
The important part is ALL vaccines are 100% effective in preventing hospitalization and death.
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
This vaccine was Moderna's very first FDA approval. A friend in pharma said for that reason alone she prefers the Pfizer vaccine since the whole process was rushed.
This vaccine was Moderna's very first FDA approval. A friend in pharma said for that reason alone she prefers the Pfizer vaccine since the whole process was rushed.
I wouldn't say "rushed" really. Expedited doesn't mean rushed. "Rushed" implies sloppiness. My understanding is that the expedited development mostly resulted from reducing regulatory-mandated time periods.
This vaccine was Moderna's very first FDA approval. A friend in pharma said for that reason alone she prefers the Pfizer vaccine since the whole process was rushed.
"Rushed" is probably one of the bigger misunderstandings out there.
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
I would give this some sort of award if it were on reddit.
At this point who cares. The trials ended in November. Since then millions of people around the world have gotten the Pfizer and Moderna vaccines. Look at the results. These vaccines are as good as advertised both in terms of safety and efficacy.
NFT: Moderna vs. Pfizer Vaccines - Which is better?
both the Pfizer and Moderna for all intent and purpose are identical. the major difference is 2nd shot for Pfizer is 21 days later, and Moderna is 28 days. There are differences in storage and handling from our standpoint, but that's not relevant for the general public.
As Bill said above, whichever vaccine you can get first, that's the one. Including J and J, it builds immunity as it goes along and reaches a comparable level after 56 days.
Had my 2nd shot last week. Knocked me on my ass for a day, had a fever between 101-103 and tired/headache. But after 24-36 hours felt fine like nothing was wrong.
This vaccine was Moderna's very first FDA approval. A friend in pharma said for that reason alone she prefers the Pfizer vaccine since the whole process was rushed.
The process was streamlined and the FDA went through their standard protocols for the requests by each company.
With people I know and myself, it seems like Pfizer’s side effects aren’t as intense as Moderna’s. I got my 2nd Moderna Friday and Saturday I was in pain. A friend I spoke to about it before I got mine who had his said “I felt like I got hit by a Mack truck” and that truly encapsulates the way I felt. Brutal headache, fever over 100, and physically just not being able to do anything but lie in bed. From 9 AM to 6 PM Saturday, this was how I felt. After I ate dinner Saturday, I almost immediately felt back to normal.
From what I understand, Moderna and Pfizer had similar efficacies after 1 shot, too. Mid-60%s. The second "booster" shot is what puts it over the top and into the mid-90%s.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
They're differing technologies. Both Pfizer and Moderna are mRNA vax's, which don't inject the actual virus into your body, but a lab-created template. J&J is the more traditional vax that does include parts of the COVID vax.
The important thing to understand about J&J's efficacy rates is that it was tested later, and in areas (S Africa and Latin America) where newer strains were spreading. I believe their efficacy in N America was around 85%.
The first shot was no big deal, my arm was sore, and I was a little fatigued the next day. The 2nd shot was a bit more intense. I felt great the day of the shot, but felt increasingly worse on day 2. Light flu symptoms - a chill, some body aches - took a nap and I was fine.
Getting my 2nd Pfizer shot on apr 21st (noon time).
I am due to play golf Friday morning (23rd)...
re: side effects, do they generally start 24 hours after the shot and last for 24 hours, thus putting my golf outing at risk? Or do they generally come on more immediately post-shot?
trying to decide my likelihood of making this outing!
(small problems, I know)
Had my 2nd shot last week. Knocked me on my ass for a day, had a fever between 101-103 and tired/headache. But after 24-36 hours felt fine like nothing was wrong.
My brother had the exact same experience. Knocked out with fever and chills for an afternoon/evening, was completely fine the next morning.
Getting my 2nd Pfizer shot on apr 21st (noon time).
I am due to play golf Friday morning (23rd)...
re: side effects, do they generally start 24 hours after the shot and last for 24 hours, thus putting my golf outing at risk? Or do they generally come on more immediately post-shot?
trying to decide my likelihood of making this outing!
(small problems, I know)
I had my second Pfizer 10 days ago. I felt a little light-headed right after, then ok, but by evening I had body aches and was pretty tired. I felt better the next day, good enough for a bike ride.
But I am not taking off my mask anytime soon. Does anyone realize why there was no flu season this year?
Yes, that's right.
Preach brother!!! Knock on wood, I have not experienced a single symptom (aside from an occasional headache) since I recovered from the flu last February. While I don’t know that I’ll always wear a mask every day the rest of my life (assuming mask mandates will eventually be lifted), but I think a lot of people will wear them during the winter months for this reason.
there's a misunderstanding. All companies who were developing vaccines starting last March, were given "limited objectives" by the FDA. The intent was to develop a vaccine for 21 and older than "prevented someone who contracts the virus from getting moderate to severe symptoms and needs hospitalization.
That's it!
So without having to do all test groups, finding out if the vaccine prevents contraction, or rep-transmission, they were able to streamline Phase 1, 2 and 3 to do a COMPLETE process in 8-12 months.
Research is ongoing. For example, both Pfizer and Moderna are safe and effective and patient populations down to 16 years. on going is studies down to 12.
Indications are these vaccines DO prevent contraction and re-transmission. studies will be ongoing for YEARS yet.
This is why they ALL have EUAs (emergency use authorization)
For people who say "I don't know what they can do to me in the future!" Fair sentiment, but as the variants become more lethal, COVID WILL kill you in greater percentages.
Get the vaccine, its the better percentage play!!
Hope this helps.
RE: RE: One thing I never understood regarding J&J
From what I understand, Moderna and Pfizer had similar efficacies after 1 shot, too. Mid-60%s. The second "booster" shot is what puts it over the top and into the mid-90%s.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
They're differing technologies. Both Pfizer and Moderna are mRNA vax's, which don't inject the actual virus into your body, but a lab-created template. J&J is the more traditional vax that does include parts of the COVID vax.
The important thing to understand about J&J's efficacy rates is that it was tested later, and in areas (S Africa and Latin America) where newer strains were spreading. I believe their efficacy in N America was around 85%.
The idea is that antibodies bind to foreign proteins (that's simplistic, but for the sake of discussion...) and for this virus that binding prevents the virus from infecting your cells If you think back to your bio classes, proteins are made off of a mRNA template and the mRNA is made off of a DNA template (simplistically). Pfizer and Moderna simply provide that mRNA template to your cells and lets your cells' protein-making machinery make the proteins. The viruses are a pretty whopping amount of mRNA that your cells pick up and use to make proteins, just as if it was your own mRNA. But once that mRNA is used up, there is no more protein and nothing left to stimulate the immune response.
J&J takes the DNA that will make the mRNA and stitches it into the DNA of a harmless virus. That virus infects your cells and, as viruses do, the virus takes over your protein-making machinery to make the viral proteins (one of which is now the coronavirus protein). The virus also grows and spreads to infect other cells before the immune system catches up to it an quashes the infection. So, here you're starting with a smaller amount of COVID mRNA and waiting until the virus grows and produces a lot. It's a slow burn versus a fast fire. But, because it's an actual virus, you get a longer period in which to stimulate the immune response (basically until all the virus is cleared) and the vaccine can bring a lot of immune elements into the picture so that you can make a vigorous responses. Some of that makes it so you don't need the second dose like you do with the quick-burning mRNA
The first shot no side effects other than both of us felt like someone hit us in the arm with a sledgehammer. We were both happy we got the Pfizer shot for the only reason we had heard Moderna side effects were worse but that is only threw friends so really no evidence it's true.
Curious if anyone has heard or knows if this will need to be a yearly vaccine like the flu shot or not?
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
BRAVO!
RE: My wife and I get our second Pfizer shot next Tuesday
The first shot no side effects other than both of us felt like someone hit us in the arm with a sledgehammer. We were both happy we got the Pfizer shot for the only reason we had heard Moderna side effects were worse but that is only threw friends so really no evidence it's true.
Curious if anyone has heard or knows if this will need to be a yearly vaccine like the flu shot or not?
My personal opinion is that...it depends.
If we get *really* good buy-in, and that includes convince the anti-vaxxers and the "vaccine hesitants" to overcome their objections (even if it's done by policy, which I have no aversion toward but don't think will happen), and this includes, because of travel, everywhere in the world, then I don't think there would be a need. The virus can be quashed.
If vaccination isn't as successful or as speedy, then there is a possibility that we will need boosters because the unvaccinated will become a breeding ground for mutations that escape the vaccine response.
There is a third possibility and that is the S African variant escapes a lot of the vaccine response (not all) to the current vaccines. But, there is data which shows that if you're infected with the S. African variant first, you are immune to the earlier (and other variants) virus. SO, potentially, if they switch the vaccine over to the S. African virus, which both Moderna and Pfizer (probably the rest too) are beginning to do, then you might have broader protection which would include immunity against new variants
But they won’t know until late this yr or 2022
FLU. Gonna be dangerous later this yr
Reason is there is little data from current flu season to put together a proper flu shot
They are always doing their best guess scenario for next yrs flu vax. Next yr will be more difficult
Probably a good reason to mask up in crowded public areas at for another yr and keep hand sanitizer/ washings hands as protocol, probably forever
Which is a good thing since that is a great way to keep flu down every yr.
vs Covid/one of its variants, just like common flu booster is recommended to protect against the prevalent strain of flu for the vaccination year. all imo
Posted this on another thread:
https://www.washingtonpost.com/world/2021/04/05/brazil-variant-coronavirus-south-america/
As with the 1st Pfizer vaccine, only some very minor pain at the site of the injection. For me, zero difference at the injection site from a flu shot.
My wife and I got the 1st Pfizer on the same day (late in the day, around 5 PM), both of us had a very restless night's sleep (I probably woke up 4 or 5 times; same with her). After the 2nd shot (which I got at around 7:30 AM), I didn't get a good night's sleep either.
Zero other symptoms for me. I was very physically active both the day of 2nd Pfizer shot and the day after; no issues.
Anecdotally, it seems as if the Moderna vaccine has more initial side effects. My daughter and son in law got Moderna and both felt crummy for a day or two with flu like symptoms.
My son got Pfizer, no issues.
As others have stated, Pfizer and Moderna use the same technology. I wanted Pfizer for the reasons others had stated (more established company, shorter time between vaccinations). My mother in law has a very well regarded cardiologist. He had got the Pfizer and recommended she get Pfizer.
But as others have stated, the most important thing is get some kind of vaccine as early as you can.
I still have some friends that aren't comfortable getting any vaccines. I think they're make a poor choice.
RE: High likelihood that it will be recommended to receive annual boosters
vs Covid/one of its variants, just like common flu booster is recommended to protect against the prevalent strain of flu for the vaccination year. all imo
Posted this on another thread:
https://www.washingtonpost.com/world/2021/04/05/brazil-variant-coronavirus-south-america/
This strain is hitting BC province hard
yes it does seem annual boosters will be in the cards for at least the next few years until (or if) this virulent strain of covid is eradicated.
Some are taking my "rushed" comment in the wrong direction
No where did I say "don't get vaccinated" or even "don't take Moderna." Getting vaccinated is the most important thing. But many here are also correctly pointing out that research is still ongoing and there are still unknowns for several groups. Given that, if I have equal choice of Moderna vs. Pfizer (the question in the OP), I'm picking the more reputable company that's been doing this for a long time. That's it. Do what you want.
My wife and I got our first dose of Pfizer on the same day at separate facilities. I had a very mild reaction, barely noticeable. My wife got quite sick with "flu-like" symptoms for about 3 days.
I had my second dose last week and I had a more noticeable reaction: Headache, body aches, maybe a low-grade fever. Set in about 8 hours after the shot and lasted about 36 hours. Got the shot on Wednesday morning; Friday morning I felt fine.
My wife gets her second shot on Wednesday and is planning on another bad reaction. Her immune system always sort of "goes to 11" so we weren't surprised that she had a strong reaction.
I'd advise your wife to take Thursday off if she's getting it Wednesday just in case she has bad reaction. My wife was bedridden for 2 days after her second shot.
The clinical trials of Pfizer were marginally better than Moderna but in real world data available recently both are tracking around 90% efficacy after 2nd shot to prevent infection. The real world data, as opposed to the clinical trials, seems to indicate that the vaccine *prevents* infection and does merely mitigate the symptoms of the disease. This is an important and nearly miraculous element to the vaccine. As far as I know, there are no cases of anyone being vaccinated and subsequently dying from covid. So even if you get vaccine and then get covid, which is highly unlikely, your overwhelming probability is for a mild and eminently survivable case.
The J&J vaccine is also highly effective though maybe slightly less effective in the after shot near term. However, there's considerable thought that the J&J vaccine may offer very similar efficacy over a broader timeline.
Regardless, get vaccinated. We're in a race now with the variants so the more people vaccinated the less people this horrible virus can infect.
Woke up the next morning feeling a little off. In the early afternoon, about 22 hours after the shot, it really started to hit me. I had symptoms similar to early onset of a cold or the flu - mild fever, chills, body aches, etc.
I took Tylenol every four hours and chugged a bunch of Gatorade. When I woke up the next morning, I was fine.
If you have a choice of which vaccine to get, and this includes the Janssen (J&J), get the one which you can have first.
Bill nailed it. The question isn't which has the highest efficacy (which is merely a snapshot measuring how effective the vaccine performed in clinical trails at preventing infection). This is largely meaningless once the vaccines are approved because efficacy changes as the virus mutates and population pool changes. The important question is which vaccine will keep you alive and out of the hospital. That's all of them.
Don't vaccine shop. Just get one. Here's an excellent video explaining this in depth.
Katalin Kariko, a Hungarian-born biochemist and professor at University of Pennsylvania first raised the idea of using mRNA as a means of gene therapy in 1990. She was demoted in 1995 after being rejected for several grants to begin research on mRNA which was seen as a dead end.
Fast forward. She is now a Senior VP at BioNtech and hailed as the mother of mRNA based Covid-19 vaccines.
RE: RE: High likelihood that it will be recommended to receive annual boosters
yes it does seem annual boosters will be in the cards for at least the next few years until (or if) this virulent strain of covid is eradicated.
Expect it to be ongoing for the foreseeable future. As long as COVID persists anywhere in the world it will mutate. The third world has barely been touched by vaccines at this point. And given that the drive to eradicate polio has gone on for decades and still hasn’t succeeded, it’s unlikely COVID can be eradicated worldwide. So: regular boosters will be in our future.
The only viable way to stop the need for annual boosters is to develop a vaccine that works against ALL coronaviruses. Scientists began working on it after SARS & MERS, but they lost funding since those diseases were stopped with few deaths. Well, they’ve got funding now. They are optimistic about the project, but we’ll have to wait and see.
shot on Friday 4/23. Next day I have a 4 hour outdoor gig to play with my band. I'm dreading side effects, because performing with fever sucks. I tried to reschedule the shot but it's next to impossible.
Advice I got was to just do it and not play games with the appointment.
As I mentioned I got the first Moderna vaccine shot this morning...
shot on Friday 4/23. Next day I have a 4 hour outdoor gig to play with my band. I'm dreading side effects, because performing with fever sucks. I tried to reschedule the shot but it's next to impossible.
Advice I got was to just do it and not play games with the appointment.
Good luck. FWIW, I had no adverse reaction to my 2nd Moderna.
Which vaccine is less likely to have deep-state mind control elements?
as did my wife. I had a sore arm for a day after the second dose. She had chills and felt very weak for several hours. Daughter got the J&J shot with no side effects and neighbors got Moderna with no side effects. Have yet to hear of anyone who regrets getting the vaccine though.
on friday at 2pm. the second shot stung like a B where the first I did t realize the guy stuck me. Arm was 1000x worse than the first. By 1am minor chills and aches. slept well. woke up feeling like I was tackled by James Harrison. Body aches all over. by 11am full on flu like symptoms just about as bad as any flu I have had. 8pm felt normal. Arm stopped hurting today but I have a massive headache. not sure if shot or just weather
Who have a lot of doctors as their clients, that for younger people the Pfizer vaccine has shown less side effects. In fact, many of my clients who do a lot of work with doctors have gone out of their way to drive to/find locations where they could specifically get the Pfizer vaccine.
I have no idea if it is proven that the Pfizer vaccine has less side effects for younger people, but that is what I have heard. Please don’t take the above as factual/completely accurate. Purely anecdotal.
Who have a lot of doctors as their clients, that for younger people the Pfizer vaccine has shown less side effects. In fact, many of my clients who do a lot of work with doctors have gone out of their way to drive to/find locations where they could specifically get the Pfizer vaccine.
I have no idea if it is proven that the Pfizer vaccine has less side effects for younger people, but that is what I have heard. Please don’t take the above as factual/completely accurate. Purely anecdotal.
Physicians I know have bascially said whatever you can get sooner of Moderna v. Pfizer you should take. The only contraindication is that if you have had anaphylactic reaction in the past you are better off getting Moderna.
You are absolutely correct. That is why it came to market so fast because they basically were tweaking what they had. Additionally the mRNA vaccines (Pfizer and Moderna) are easier to tweak and because of this, they will be relatively easy to adapt to new variants and down the road for booster shots. Nonetheless, it was a Herculean effort to perfect a vaccine with 94.1(Moderna) and 95.0 (Pfizer) efficacy.
Choosing it based on the Randomness of Fauci is as dumb as avoiding it based on the Randomness of Fauci.
Bill L, I know 5 or so people who said they refuse to get J&J because it's not as effective as Pfizer or Moderna. I just said...GET WHATEVER YOU CAN GET. People can be so dense.
Choosing it based on the Randomness of Fauci is as dumb as avoiding it based on the Randomness of Fauci.
Bill L, I know 5 or so people who said they refuse to get J&J because it's not as effective as Pfizer or Moderna. I just said...GET WHATEVER YOU CAN GET. People can be so dense.
Yup. But even those dummies are like Mensa members compared to the ones who won’t get any at all.
Moderna COVID Vaccine has more side effects than Pfizer-BioNTech:
Nearly 51 per cent of Moderna recipients had full-body symptoms, compared with 48 per cent of people who got the Pfizer/BioNTech shot. The gap widened after the second dose.
2nd shot:
"Overall, 74 per cent of people said they had general reactions after their Moderna shot, compared with 64 per cent of people getting Pfizer/BioNTech," the report said on Tuesday.
If you have a choice of which vaccine to get, and this includes the Janssen (J&J), get the one which you can have first.
They are, for all intents and purposes, the same thing.
"get whichever one they're willing to inject in your arm"
I got the Moderna. They're both the same.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
If you have a choice of which vaccine to get, and this includes the Janssen (J&J), get the one which you can have first.
This. In my family, we will have vaccine bingo.
My wife got Moderna. I have one shot of Pfizer and our oldest has one shot of Moderna. Two of the kids home from college this week are getting J&J one and done tomorrow. Our youngest gets Pfizer Thursday. It doesn't really matter which you get. Just get one. They're all extremely effective at reducing the impact of the virus.
Regarding the comparison of efficacy, it's important to note that these vaccines were tested individually for efficacy and not in a head to head comparison. That means they were tested at different times with different strains prevalent at the those times. Different populations and different locations. The results are not ideally suited for comparison as they were only intended to determine if they are effective at preventing infection and reducing the illness if infection occurs.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
I believe they are testing this now.
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
My wife have a reaction. But not as severe
mom & dad / mom was ok / dad got messed up from moderna
Sister got jacked up from Pfizer her husband ok
It’s basically all the same stuff.
This morning, it felt like my big ass brother punched my arm, like we were kids. Other than that, nothing
Get my 2nd on the 25th
As someone has already said, you should probably take whichever one you can get first.
Tetanus
MMR?
All of a sudden every internet cowboy is an expert.
Yeah it doesn't matter.
This should have all the info you need - ( New Window )
Whos to say how the date would change if the clinical trial time periods were switched.
The important part is ALL vaccines are 100% effective in preventing hospitalization and death.
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
Thanks, this helped!
I wouldn't say "rushed" really. Expedited doesn't mean rushed. "Rushed" implies sloppiness. My understanding is that the expedited development mostly resulted from reducing regulatory-mandated time periods.
"Rushed" is probably one of the bigger misunderstandings out there.
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
I would give this some sort of award if it were on reddit.
Great link
In terms of overall protection, no difference.
And if there is a difference, I have not read or heard one scientist say so.
https://www.vox.com/22362894/which-covid-vaccine-is-better-moderna-vs-pfizer-video
Sorry I couldn't get to link.
As Bill said above, whichever vaccine you can get first, that's the one. Including J and J, it builds immunity as it goes along and reaches a comparable level after 56 days.
https://www.vox.com/22362894/which-covid-vaccine-is-better-moderna-vs-pfizer-video
Sorry I couldn't get to link.
Wow, thanks for this. I learned something.
Here's a link to it:
https://www.youtube.com/watch?v=K3odScka55A
Link - ( New Window )
The process was streamlined and the FDA went through their standard protocols for the requests by each company.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
They're differing technologies. Both Pfizer and Moderna are mRNA vax's, which don't inject the actual virus into your body, but a lab-created template. J&J is the more traditional vax that does include parts of the COVID vax.
The important thing to understand about J&J's efficacy rates is that it was tested later, and in areas (S Africa and Latin America) where newer strains were spreading. I believe their efficacy in N America was around 85%.
This morning, it felt like my big ass brother punched my arm, like we were kids. Other than that, nothing
Get my 2nd on the 25th
Got my first Pfizer shot on Saturday. Same reaction. Sore arm and nothing else.
I think the moral of the story is there are varied effects, but none serious enough to even blink at getting the earliest available to you.
Yes, that's right.
I am due to play golf Friday morning (23rd)...
re: side effects, do they generally start 24 hours after the shot and last for 24 hours, thus putting my golf outing at risk? Or do they generally come on more immediately post-shot?
trying to decide my likelihood of making this outing!
(small problems, I know)
My brother had the exact same experience. Knocked out with fever and chills for an afternoon/evening, was completely fine the next morning.
I am due to play golf Friday morning (23rd)...
re: side effects, do they generally start 24 hours after the shot and last for 24 hours, thus putting my golf outing at risk? Or do they generally come on more immediately post-shot?
trying to decide my likelihood of making this outing!
(small problems, I know)
I had my second Pfizer 10 days ago. I felt a little light-headed right after, then ok, but by evening I had body aches and was pretty tired. I felt better the next day, good enough for a bike ride.
Yes, that's right.
Preach brother!!! Knock on wood, I have not experienced a single symptom (aside from an occasional headache) since I recovered from the flu last February. While I don’t know that I’ll always wear a mask every day the rest of my life (assuming mask mandates will eventually be lifted), but I think a lot of people will wear them during the winter months for this reason.
That's it!
So without having to do all test groups, finding out if the vaccine prevents contraction, or rep-transmission, they were able to streamline Phase 1, 2 and 3 to do a COMPLETE process in 8-12 months.
Research is ongoing. For example, both Pfizer and Moderna are safe and effective and patient populations down to 16 years. on going is studies down to 12.
Indications are these vaccines DO prevent contraction and re-transmission. studies will be ongoing for YEARS yet.
This is why they ALL have EUAs (emergency use authorization)
For people who say "I don't know what they can do to me in the future!" Fair sentiment, but as the variants become more lethal, COVID WILL kill you in greater percentages.
Get the vaccine, its the better percentage play!!
Hope this helps.
Quote:
From what I understand, Moderna and Pfizer had similar efficacies after 1 shot, too. Mid-60%s. The second "booster" shot is what puts it over the top and into the mid-90%s.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
They're differing technologies. Both Pfizer and Moderna are mRNA vax's, which don't inject the actual virus into your body, but a lab-created template. J&J is the more traditional vax that does include parts of the COVID vax.
The important thing to understand about J&J's efficacy rates is that it was tested later, and in areas (S Africa and Latin America) where newer strains were spreading. I believe their efficacy in N America was around 85%.
The idea is that antibodies bind to foreign proteins (that's simplistic, but for the sake of discussion...) and for this virus that binding prevents the virus from infecting your cells If you think back to your bio classes, proteins are made off of a mRNA template and the mRNA is made off of a DNA template (simplistically). Pfizer and Moderna simply provide that mRNA template to your cells and lets your cells' protein-making machinery make the proteins. The viruses are a pretty whopping amount of mRNA that your cells pick up and use to make proteins, just as if it was your own mRNA. But once that mRNA is used up, there is no more protein and nothing left to stimulate the immune response.
J&J takes the DNA that will make the mRNA and stitches it into the DNA of a harmless virus. That virus infects your cells and, as viruses do, the virus takes over your protein-making machinery to make the viral proteins (one of which is now the coronavirus protein). The virus also grows and spreads to infect other cells before the immune system catches up to it an quashes the infection. So, here you're starting with a smaller amount of COVID mRNA and waiting until the virus grows and produces a lot. It's a slow burn versus a fast fire. But, because it's an actual virus, you get a longer period in which to stimulate the immune response (basically until all the virus is cleared) and the vaccine can bring a lot of immune elements into the picture so that you can make a vigorous responses. Some of that makes it so you don't need the second dose like you do with the quick-burning mRNA
The common theme is some had no symptoms, some did, but they went away within a day or two. That's the norm.
Curious if anyone has heard or knows if this will need to be a yearly vaccine like the flu shot or not?
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
BRAVO!
Curious if anyone has heard or knows if this will need to be a yearly vaccine like the flu shot or not?
My personal opinion is that...it depends.
If we get *really* good buy-in, and that includes convince the anti-vaxxers and the "vaccine hesitants" to overcome their objections (even if it's done by policy, which I have no aversion toward but don't think will happen), and this includes, because of travel, everywhere in the world, then I don't think there would be a need. The virus can be quashed.
If vaccination isn't as successful or as speedy, then there is a possibility that we will need boosters because the unvaccinated will become a breeding ground for mutations that escape the vaccine response.
There is a third possibility and that is the S African variant escapes a lot of the vaccine response (not all) to the current vaccines. But, there is data which shows that if you're infected with the S. African variant first, you are immune to the earlier (and other variants) virus. SO, potentially, if they switch the vaccine over to the S. African virus, which both Moderna and Pfizer (probably the rest too) are beginning to do, then you might have broader protection which would include immunity against new variants
FLU. Gonna be dangerous later this yr
Reason is there is little data from current flu season to put together a proper flu shot
They are always doing their best guess scenario for next yrs flu vax. Next yr will be more difficult
Probably a good reason to mask up in crowded public areas at for another yr and keep hand sanitizer/ washings hands as protocol, probably forever
Which is a good thing since that is a great way to keep flu down every yr.
Posted this on another thread:
https://www.washingtonpost.com/world/2021/04/05/brazil-variant-coronavirus-south-america/
This strain is hitting BC province hard
My wife and I got the 1st Pfizer on the same day (late in the day, around 5 PM), both of us had a very restless night's sleep (I probably woke up 4 or 5 times; same with her). After the 2nd shot (which I got at around 7:30 AM), I didn't get a good night's sleep either.
Zero other symptoms for me. I was very physically active both the day of 2nd Pfizer shot and the day after; no issues.
Anecdotally, it seems as if the Moderna vaccine has more initial side effects. My daughter and son in law got Moderna and both felt crummy for a day or two with flu like symptoms.
My son got Pfizer, no issues.
As others have stated, Pfizer and Moderna use the same technology. I wanted Pfizer for the reasons others had stated (more established company, shorter time between vaccinations). My mother in law has a very well regarded cardiologist. He had got the Pfizer and recommended she get Pfizer.
But as others have stated, the most important thing is get some kind of vaccine as early as you can.
I still have some friends that aren't comfortable getting any vaccines. I think they're make a poor choice.
Posted this on another thread:
https://www.washingtonpost.com/world/2021/04/05/brazil-variant-coronavirus-south-america/
This strain is hitting BC province hard
yes it does seem annual boosters will be in the cards for at least the next few years until (or if) this virulent strain of covid is eradicated.
I had my second dose last week and I had a more noticeable reaction: Headache, body aches, maybe a low-grade fever. Set in about 8 hours after the shot and lasted about 36 hours. Got the shot on Wednesday morning; Friday morning I felt fine.
My wife gets her second shot on Wednesday and is planning on another bad reaction. Her immune system always sort of "goes to 11" so we weren't surprised that she had a strong reaction.
The J&J vaccine is also highly effective though maybe slightly less effective in the after shot near term. However, there's considerable thought that the J&J vaccine may offer very similar efficacy over a broader timeline.
Regardless, get vaccinated. We're in a race now with the variants so the more people vaccinated the less people this horrible virus can infect.
So basically zero side effects
I took Tylenol every four hours and chugged a bunch of Gatorade. When I woke up the next morning, I was fine.
If you have a choice of which vaccine to get, and this includes the Janssen (J&J), get the one which you can have first.
Bill nailed it. The question isn't which has the highest efficacy (which is merely a snapshot measuring how effective the vaccine performed in clinical trails at preventing infection). This is largely meaningless once the vaccines are approved because efficacy changes as the virus mutates and population pool changes. The important question is which vaccine will keep you alive and out of the hospital. That's all of them.
Don't vaccine shop. Just get one. Here's an excellent video explaining this in depth.
Why you can't compare Covid-19 vaccines - ( New Window )
Fast forward. She is now a Senior VP at BioNtech and hailed as the mother of mRNA based Covid-19 vaccines.
yes it does seem annual boosters will be in the cards for at least the next few years until (or if) this virulent strain of covid is eradicated.
Expect it to be ongoing for the foreseeable future. As long as COVID persists anywhere in the world it will mutate. The third world has barely been touched by vaccines at this point. And given that the drive to eradicate polio has gone on for decades and still hasn’t succeeded, it’s unlikely COVID can be eradicated worldwide. So: regular boosters will be in our future.
The only viable way to stop the need for annual boosters is to develop a vaccine that works against ALL coronaviruses. Scientists began working on it after SARS & MERS, but they lost funding since those diseases were stopped with few deaths. Well, they’ve got funding now. They are optimistic about the project, but we’ll have to wait and see.
Advice I got was to just do it and not play games with the appointment.
As I mentioned I think I'd prefer the Pfizer shot. I may have had the option, but it never occurred to me to request it.
:mad:
Advice I got was to just do it and not play games with the appointment.
Good luck. FWIW, I had no adverse reaction to my 2nd Moderna.
I don't want my brain to be overcome by crazy ideas.
I don't want my brain to be overcome by crazy ideas.
Too late.
No side effects.
I don't want my brain to be overcome by crazy ideas.
Yes, that's right.
It only stupidity as fatal
I have no idea if it is proven that the Pfizer vaccine has less side effects for younger people, but that is what I have heard. Please don’t take the above as factual/completely accurate. Purely anecdotal.
I have no idea if it is proven that the Pfizer vaccine has less side effects for younger people, but that is what I have heard. Please don’t take the above as factual/completely accurate. Purely anecdotal.
Physicians I know have bascially said whatever you can get sooner of Moderna v. Pfizer you should take. The only contraindication is that if you have had anaphylactic reaction in the past you are better off getting Moderna.
I don't want my brain to be overcome by crazy ideas.
Why do you post here then? :)
Still a bit sore and tired, but no headache.
30 years.
Quote:
But I am not taking off my mask anytime soon. Does anyone realize why there was no flu season this year?
Yes, that's right.
It only stupidity as fatal
Unintentionally ironic post of the year right there by LM.
:thumbsup:
Wife is completely laid up for the day. She feels like crap.
My arm is sore, a little tired, a little sore nthing crazy
Wife is completely laid up for the day. She feels like crap.
This too shall pass. You both should be feeling good soon.
:thumbsup:
Quote:
that Fauci got the Moderna vacccine, so that makes me feel better!
:thumbsup:
Then I’m glad I got the Pfizer
Some of you people are weird.
Bill L, I know 5 or so people who said they refuse to get J&J because it's not as effective as Pfizer or Moderna. I just said...GET WHATEVER YOU CAN GET. People can be so dense.
Quote:
Choosing it based on the Randomness of Fauci is as dumb as avoiding it based on the Randomness of Fauci.
Bill L, I know 5 or so people who said they refuse to get J&J because it's not as effective as Pfizer or Moderna. I just said...GET WHATEVER YOU CAN GET. People can be so dense.
Yup. But even those dummies are like Mensa members compared to the ones who won’t get any at all.
I sort of expected this.
:sad:
https://www.indiatvnews.com/news/world/moderna-covid-vaccine-has-more-side-effects-than-pfizer-biontech-study-696258 - ( New Window )
Nearly 51 per cent of Moderna recipients had full-body symptoms, compared with 48 per cent of people who got the Pfizer/BioNTech shot. The gap widened after the second dose.
2nd shot:
"Overall, 74 per cent of people said they had general reactions after their Moderna shot, compared with 64 per cent of people getting Pfizer/BioNTech," the report said on Tuesday.