Both are nearly identical in terms of protection, in the 95% range. More importantly, just get whatever you can. Not a dig @ you, but I have friends who are passing on J&J because they want Moderna or Pfizer. I believe J&J is something like 66% effective, but still...it will limit you getting really sick if you do get COVID & that's the whole point of the vaccines...to reduce hospitalizations/deaths.
Pfizer’s effacy numbers are slightly better, but considering the way these are calculated, I’d say the difference is negligible. Side effects are basically the same and driven by individual immune system response based on age, health, allergy history and possibly even blood type. The only real benefit I see is the wait time between 1st and 2nd shots is 3 weeks for Pfizer vs 4 weeks for Moderna. But you are good to go with either one.
From what I understand, Moderna and Pfizer had similar efficacies after 1 shot, too. Mid-60%s. The second "booster" shot is what puts it over the top and into the mid-90%s.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
If you have a choice of which vaccine to get, and this includes the Janssen (J&J), get the one which you can have first.
This. In my family, we will have vaccine bingo.
My wife got Moderna. I have one shot of Pfizer and our oldest has one shot of Moderna. Two of the kids home from college this week are getting J&J one and done tomorrow. Our youngest gets Pfizer Thursday. It doesn't really matter which you get. Just get one. They're all extremely effective at reducing the impact of the virus.
Regarding the comparison of efficacy, it's important to note that these vaccines were tested individually for efficacy and not in a head to head comparison. That means they were tested at different times with different strains prevalent at the those times. Different populations and different locations. The results are not ideally suited for comparison as they were only intended to determine if they are effective at preventing infection and reducing the illness if infection occurs.
From what I understand, Moderna and Pfizer had similar efficacies after 1 shot, too. Mid-60%s. The second "booster" shot is what puts it over the top and into the mid-90%s.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
Pfizer and Moderna are similar vaccines that went through similar trials and came out with similar results. J&J is a different sort of vaccine and went through a different trial testing for different outcomes and had good results.
As someone has already said, you should probably take whichever one you can get first.
Yes the clinical efficacy of Pfizer and Moderna are higher but their Phase 3 trial was conducted during the late summer when COVID worldwide was at its lowest since April. Whereas J&J with it's lower efficacy was conducted mid winter during the highest period of worldwide COVID cases to date, AND with the rise of more contagious and severe variants.
Whos to say how the date would change if the clinical trial time periods were switched.
The important part is ALL vaccines are 100% effective in preventing hospitalization and death.
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
This vaccine was Moderna's very first FDA approval. A friend in pharma said for that reason alone she prefers the Pfizer vaccine since the whole process was rushed.
This vaccine was Moderna's very first FDA approval. A friend in pharma said for that reason alone she prefers the Pfizer vaccine since the whole process was rushed.
I wouldn't say "rushed" really. Expedited doesn't mean rushed. "Rushed" implies sloppiness. My understanding is that the expedited development mostly resulted from reducing regulatory-mandated time periods.
This vaccine was Moderna's very first FDA approval. A friend in pharma said for that reason alone she prefers the Pfizer vaccine since the whole process was rushed.
"Rushed" is probably one of the bigger misunderstandings out there.
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
I would give this some sort of award if it were on reddit.
At this point who cares. The trials ended in November. Since then millions of people around the world have gotten the Pfizer and Moderna vaccines. Look at the results. These vaccines are as good as advertised both in terms of safety and efficacy.
NFT: Moderna vs. Pfizer Vaccines - Which is better?
both the Pfizer and Moderna for all intent and purpose are identical. the major difference is 2nd shot for Pfizer is 21 days later, and Moderna is 28 days. There are differences in storage and handling from our standpoint, but that's not relevant for the general public.
As Bill said above, whichever vaccine you can get first, that's the one. Including J and J, it builds immunity as it goes along and reaches a comparable level after 56 days.
Had my 2nd shot last week. Knocked me on my ass for a day, had a fever between 101-103 and tired/headache. But after 24-36 hours felt fine like nothing was wrong.
This vaccine was Moderna's very first FDA approval. A friend in pharma said for that reason alone she prefers the Pfizer vaccine since the whole process was rushed.
The process was streamlined and the FDA went through their standard protocols for the requests by each company.
With people I know and myself, it seems like Pfizer’s side effects aren’t as intense as Moderna’s. I got my 2nd Moderna Friday and Saturday I was in pain. A friend I spoke to about it before I got mine who had his said “I felt like I got hit by a Mack truck” and that truly encapsulates the way I felt. Brutal headache, fever over 100, and physically just not being able to do anything but lie in bed. From 9 AM to 6 PM Saturday, this was how I felt. After I ate dinner Saturday, I almost immediately felt back to normal.
From what I understand, Moderna and Pfizer had similar efficacies after 1 shot, too. Mid-60%s. The second "booster" shot is what puts it over the top and into the mid-90%s.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
They're differing technologies. Both Pfizer and Moderna are mRNA vax's, which don't inject the actual virus into your body, but a lab-created template. J&J is the more traditional vax that does include parts of the COVID vax.
The important thing to understand about J&J's efficacy rates is that it was tested later, and in areas (S Africa and Latin America) where newer strains were spreading. I believe their efficacy in N America was around 85%.
The first shot was no big deal, my arm was sore, and I was a little fatigued the next day. The 2nd shot was a bit more intense. I felt great the day of the shot, but felt increasingly worse on day 2. Light flu symptoms - a chill, some body aches - took a nap and I was fine.
Getting my 2nd Pfizer shot on apr 21st (noon time).
I am due to play golf Friday morning (23rd)...
re: side effects, do they generally start 24 hours after the shot and last for 24 hours, thus putting my golf outing at risk? Or do they generally come on more immediately post-shot?
trying to decide my likelihood of making this outing!
(small problems, I know)
Had my 2nd shot last week. Knocked me on my ass for a day, had a fever between 101-103 and tired/headache. But after 24-36 hours felt fine like nothing was wrong.
My brother had the exact same experience. Knocked out with fever and chills for an afternoon/evening, was completely fine the next morning.
Getting my 2nd Pfizer shot on apr 21st (noon time).
I am due to play golf Friday morning (23rd)...
re: side effects, do they generally start 24 hours after the shot and last for 24 hours, thus putting my golf outing at risk? Or do they generally come on more immediately post-shot?
trying to decide my likelihood of making this outing!
(small problems, I know)
I had my second Pfizer 10 days ago. I felt a little light-headed right after, then ok, but by evening I had body aches and was pretty tired. I felt better the next day, good enough for a bike ride.
But I am not taking off my mask anytime soon. Does anyone realize why there was no flu season this year?
Yes, that's right.
Preach brother!!! Knock on wood, I have not experienced a single symptom (aside from an occasional headache) since I recovered from the flu last February. While I don’t know that I’ll always wear a mask every day the rest of my life (assuming mask mandates will eventually be lifted), but I think a lot of people will wear them during the winter months for this reason.
there's a misunderstanding. All companies who were developing vaccines starting last March, were given "limited objectives" by the FDA. The intent was to develop a vaccine for 21 and older than "prevented someone who contracts the virus from getting moderate to severe symptoms and needs hospitalization.
That's it!
So without having to do all test groups, finding out if the vaccine prevents contraction, or rep-transmission, they were able to streamline Phase 1, 2 and 3 to do a COMPLETE process in 8-12 months.
Research is ongoing. For example, both Pfizer and Moderna are safe and effective and patient populations down to 16 years. on going is studies down to 12.
Indications are these vaccines DO prevent contraction and re-transmission. studies will be ongoing for YEARS yet.
This is why they ALL have EUAs (emergency use authorization)
For people who say "I don't know what they can do to me in the future!" Fair sentiment, but as the variants become more lethal, COVID WILL kill you in greater percentages.
Get the vaccine, its the better percentage play!!
Hope this helps.
RE: RE: One thing I never understood regarding J&J
From what I understand, Moderna and Pfizer had similar efficacies after 1 shot, too. Mid-60%s. The second "booster" shot is what puts it over the top and into the mid-90%s.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
They're differing technologies. Both Pfizer and Moderna are mRNA vax's, which don't inject the actual virus into your body, but a lab-created template. J&J is the more traditional vax that does include parts of the COVID vax.
The important thing to understand about J&J's efficacy rates is that it was tested later, and in areas (S Africa and Latin America) where newer strains were spreading. I believe their efficacy in N America was around 85%.
The idea is that antibodies bind to foreign proteins (that's simplistic, but for the sake of discussion...) and for this virus that binding prevents the virus from infecting your cells If you think back to your bio classes, proteins are made off of a mRNA template and the mRNA is made off of a DNA template (simplistically). Pfizer and Moderna simply provide that mRNA template to your cells and lets your cells' protein-making machinery make the proteins. The viruses are a pretty whopping amount of mRNA that your cells pick up and use to make proteins, just as if it was your own mRNA. But once that mRNA is used up, there is no more protein and nothing left to stimulate the immune response.
J&J takes the DNA that will make the mRNA and stitches it into the DNA of a harmless virus. That virus infects your cells and, as viruses do, the virus takes over your protein-making machinery to make the viral proteins (one of which is now the coronavirus protein). The virus also grows and spreads to infect other cells before the immune system catches up to it an quashes the infection. So, here you're starting with a smaller amount of COVID mRNA and waiting until the virus grows and produces a lot. It's a slow burn versus a fast fire. But, because it's an actual virus, you get a longer period in which to stimulate the immune response (basically until all the virus is cleared) and the vaccine can bring a lot of immune elements into the picture so that you can make a vigorous responses. Some of that makes it so you don't need the second dose like you do with the quick-burning mRNA
If you have a choice of which vaccine to get, and this includes the Janssen (J&J), get the one which you can have first.
They are, for all intents and purposes, the same thing.
"get whichever one they're willing to inject in your arm"
I got the Moderna. They're both the same.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
If you have a choice of which vaccine to get, and this includes the Janssen (J&J), get the one which you can have first.
This. In my family, we will have vaccine bingo.
My wife got Moderna. I have one shot of Pfizer and our oldest has one shot of Moderna. Two of the kids home from college this week are getting J&J one and done tomorrow. Our youngest gets Pfizer Thursday. It doesn't really matter which you get. Just get one. They're all extremely effective at reducing the impact of the virus.
Regarding the comparison of efficacy, it's important to note that these vaccines were tested individually for efficacy and not in a head to head comparison. That means they were tested at different times with different strains prevalent at the those times. Different populations and different locations. The results are not ideally suited for comparison as they were only intended to determine if they are effective at preventing infection and reducing the illness if infection occurs.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
I believe they are testing this now.
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
My wife have a reaction. But not as severe
mom & dad / mom was ok / dad got messed up from moderna
Sister got jacked up from Pfizer her husband ok
It’s basically all the same stuff.
This morning, it felt like my big ass brother punched my arm, like we were kids. Other than that, nothing
Get my 2nd on the 25th
As someone has already said, you should probably take whichever one you can get first.
Tetanus
MMR?
All of a sudden every internet cowboy is an expert.
Yeah it doesn't matter.
This should have all the info you need - ( New Window )
Whos to say how the date would change if the clinical trial time periods were switched.
The important part is ALL vaccines are 100% effective in preventing hospitalization and death.
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
Thanks, this helped!
I wouldn't say "rushed" really. Expedited doesn't mean rushed. "Rushed" implies sloppiness. My understanding is that the expedited development mostly resulted from reducing regulatory-mandated time periods.
"Rushed" is probably one of the bigger misunderstandings out there.
If you prefer a lighter style vaccine, definitely consider Pfizer. Unlike thick-skinned Moderna, Pfizer vaccines have very thin, delicate skins which produce a much lighter bodied injection, with a transparent ruby red color and classic flavors of red cherry, red currant, and wild strawberry. The warmer the climate, the richer expression you may find-think cherry cola-while cool-climate Pfizer reveals more earthy flavors and savory aromas like mushroom and forest fruits.
Moderna:
Considered by many vaccine lovers to be the king of hearty vaxes, Moderna is originally from the Bordeaux region of France, where's it's most commonly blended. The Moderna vaccine has a thick, hearty skin, which, along with its seeds and stems, contributes tannin to the injections-that's the compound that makes your tongue turn prickly and dry and it's also commonly experienced in black tea. Anyone that has ever over-steeped a cup of black tea knows exactly what this sensation feels like.
I would give this some sort of award if it were on reddit.
Great link
In terms of overall protection, no difference.
And if there is a difference, I have not read or heard one scientist say so.
https://www.vox.com/22362894/which-covid-vaccine-is-better-moderna-vs-pfizer-video
Sorry I couldn't get to link.
As Bill said above, whichever vaccine you can get first, that's the one. Including J and J, it builds immunity as it goes along and reaches a comparable level after 56 days.
https://www.vox.com/22362894/which-covid-vaccine-is-better-moderna-vs-pfizer-video
Sorry I couldn't get to link.
Wow, thanks for this. I learned something.
Here's a link to it:
https://www.youtube.com/watch?v=K3odScka55A
Link - ( New Window )
The process was streamlined and the FDA went through their standard protocols for the requests by each company.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
They're differing technologies. Both Pfizer and Moderna are mRNA vax's, which don't inject the actual virus into your body, but a lab-created template. J&J is the more traditional vax that does include parts of the COVID vax.
The important thing to understand about J&J's efficacy rates is that it was tested later, and in areas (S Africa and Latin America) where newer strains were spreading. I believe their efficacy in N America was around 85%.
This morning, it felt like my big ass brother punched my arm, like we were kids. Other than that, nothing
Get my 2nd on the 25th
Got my first Pfizer shot on Saturday. Same reaction. Sore arm and nothing else.
I think the moral of the story is there are varied effects, but none serious enough to even blink at getting the earliest available to you.
Yes, that's right.
I am due to play golf Friday morning (23rd)...
re: side effects, do they generally start 24 hours after the shot and last for 24 hours, thus putting my golf outing at risk? Or do they generally come on more immediately post-shot?
trying to decide my likelihood of making this outing!
(small problems, I know)
My brother had the exact same experience. Knocked out with fever and chills for an afternoon/evening, was completely fine the next morning.
I am due to play golf Friday morning (23rd)...
re: side effects, do they generally start 24 hours after the shot and last for 24 hours, thus putting my golf outing at risk? Or do they generally come on more immediately post-shot?
trying to decide my likelihood of making this outing!
(small problems, I know)
I had my second Pfizer 10 days ago. I felt a little light-headed right after, then ok, but by evening I had body aches and was pretty tired. I felt better the next day, good enough for a bike ride.
Yes, that's right.
Preach brother!!! Knock on wood, I have not experienced a single symptom (aside from an occasional headache) since I recovered from the flu last February. While I don’t know that I’ll always wear a mask every day the rest of my life (assuming mask mandates will eventually be lifted), but I think a lot of people will wear them during the winter months for this reason.
That's it!
So without having to do all test groups, finding out if the vaccine prevents contraction, or rep-transmission, they were able to streamline Phase 1, 2 and 3 to do a COMPLETE process in 8-12 months.
Research is ongoing. For example, both Pfizer and Moderna are safe and effective and patient populations down to 16 years. on going is studies down to 12.
Indications are these vaccines DO prevent contraction and re-transmission. studies will be ongoing for YEARS yet.
This is why they ALL have EUAs (emergency use authorization)
For people who say "I don't know what they can do to me in the future!" Fair sentiment, but as the variants become more lethal, COVID WILL kill you in greater percentages.
Get the vaccine, its the better percentage play!!
Hope this helps.
Quote:
From what I understand, Moderna and Pfizer had similar efficacies after 1 shot, too. Mid-60%s. The second "booster" shot is what puts it over the top and into the mid-90%s.
I know that J&J has a different delivery method than the other two, but why wouldn't a second booster shot be beneficial with that one, too? Is it said different delivery method?
They're differing technologies. Both Pfizer and Moderna are mRNA vax's, which don't inject the actual virus into your body, but a lab-created template. J&J is the more traditional vax that does include parts of the COVID vax.
The important thing to understand about J&J's efficacy rates is that it was tested later, and in areas (S Africa and Latin America) where newer strains were spreading. I believe their efficacy in N America was around 85%.
The idea is that antibodies bind to foreign proteins (that's simplistic, but for the sake of discussion...) and for this virus that binding prevents the virus from infecting your cells If you think back to your bio classes, proteins are made off of a mRNA template and the mRNA is made off of a DNA template (simplistically). Pfizer and Moderna simply provide that mRNA template to your cells and lets your cells' protein-making machinery make the proteins. The viruses are a pretty whopping amount of mRNA that your cells pick up and use to make proteins, just as if it was your own mRNA. But once that mRNA is used up, there is no more protein and nothing left to stimulate the immune response.
J&J takes the DNA that will make the mRNA and stitches it into the DNA of a harmless virus. That virus infects your cells and, as viruses do, the virus takes over your protein-making machinery to make the viral proteins (one of which is now the coronavirus protein). The virus also grows and spreads to infect other cells before the immune system catches up to it an quashes the infection. So, here you're starting with a smaller amount of COVID mRNA and waiting until the virus grows and produces a lot. It's a slow burn versus a fast fire. But, because it's an actual virus, you get a longer period in which to stimulate the immune response (basically until all the virus is cleared) and the vaccine can bring a lot of immune elements into the picture so that you can make a vigorous responses. Some of that makes it so you don't need the second dose like you do with the quick-burning mRNA