(The punchline if you don't want to read all this blah, blah, blah: Devonta Smith and/or Jaylen Waddle.)
Since the talent at the very top of each Draft varies quite a lot from year to year, this is hardly a data science exercise, but here's something to consider. Below is the distribution of positions selected in the Top 10 over the past 11 Drafts (2010 - 2020):
Not surprisingly, QBs are at the very top with 23 selected in Top 10. And it's a real good bet that at least 3 (probably 4) QBs will go in the Top 10 this April.
The second most drafted position is offensive tackle with 16 players selected. It is not inconceivable, therefore, that we could see both Penei Sewell and Rashawn Slater off the Board before the Giants come to the podium. Based on most Value Boards, these would not be reaches, and we do have a history of OTs going high in the Draft.
Right behind offensive tackle is defensive end (or EDGE) with 14 players selected. 2021 is not shaping up as a glamour draft for this position. There are no Chase Youngs; no Nick & Joey Bosas; no DeForrest Buckners; etc. But, still, there are several DEs/EDGE players that have been Mocked later on in Round One. Could one of them get pushed up into the Top 10? Based on history and the premium of the position, I think there's a pretty good chance.
Stay with me now. So far, that comes to 4 QBs, 2 OTs and 1 DE going in the Top Ten. Based on most Value Boards, we can also throw in WR Ja'Marr Chase and TE Kyle Pitts**. That comes to 9 players, and after these selections, you can Mock this Draft anyway you choose, but it always leaves either Devonte Smith and/or Jason Waddle available when the Giants come to the podium.
** If I had to speculate which player may "surprisingly" drop in this draft, it might be Kyle Pitts. Undoubtedly a great player, but also a hybrid one, part TE/part WR. And history is against TEs going in the Top 10, with only two selected since the 2010 Draft.